Table 2.

Previous and Proposed Models for Cisplatin Cellular Pharmacodynamics.

Name of model	Reference	Equations	Number of free parameters
Extracellular AUC model	Ozawa et al. [9]	S=1/(1+A(AUC)m) where $\text{AUC}={\int }_{\text{O}}^T{c}_{\text{e}}(t)\text{d}t$	2
Extracellular CnT model	Skipper [14] and Adams et al. [15]	S=1/(1+A(AUCn)m) where ${\text{AUC}}^n={{\displaystyle {\int }_0^T{c}_{\text{e}}(t)}}^n\text{d}t$	3
Levasseur et al. model	Levasseur et al. [11]	$S=B+\left(S_{\text{con}}-B\right)\left(\frac{c_e^{\gamma }}{c_e^{\gamma }+{\text{IC}}_{50}^{\gamma }}\right)$ IC50=(k/T)1/n γ=γ0+γ1T+γ2T2	7
Gardner model	Gardner [16]	S=Exp[1-b(1-e-aCe)T]	2
Peak intracellular model	Present study	$S=1/(1+A{(c_{\text{i}}^{\text{peak}})}^m)$$S=1/(1+A{(c_{\text{i}}^{\text{peak}})}^m)$ and Eq. (2)	2 or 4*
Peak-bound intracellular model	Present study	$S=1/(1+A{(c_{\text{i}}^{\text{peak}})}^m)$ and Eqs. (2) and (3)	3 or 5*

^*The two parameters relating to cellular uptake may be obtained separately (see text).