Table 3.

Best-Fit Model Parameters for Cisplatin Cytotoxicity Data Sets.

Model	Parameters for Troger et al. [2] data	Parameters for Levasseur et al. [11] data	Parameters for Kurihara et al. [3] data
Extracellular AUC model	A=0.2033, m=1.229	A=0.4047, m=1.882	A=0.1786, m=0.5574
Extracellular CnT model	n=1.303, A=0.2988, m=0.9991	n=0.8762, A=0.2603, m=2.171	n=3.313, A=0.3920, m=0.1539
Levasseur et al. [11] model	k=3.670, n=1.306, B=0*, Econ=0.9811, γ0=-1.621, γ1=0.05718 hour-1, γ2=-0.0004485 hour-2	k=1.855, n=0.8683, B=0.006507, Econ=0.9974, γ0=-1.856, γ1=-0.05292 hour-1, γ2=0.002680 hour-2	k=2.832, n=1.652, B=0*, Econ=1.514, γ0=-0.4066, γ1=-0.006071 hour-1, γ0=0.0002250 hour-2
Gardner [16] model	a=0.0006284, b=271.0	a=0.1156, b=3.691	a=0.01265, b=2.077
Peak intracellular model	(k1=2.635 hour-1), ($k_1^{\prime }$ 0=0.1184 hour-1), A=0.1477, m=1.212	k1=0.04629 hour-1, $k_1^{\prime }$ 0=0.0002569 hour-1, A=131.4, m=1.881	(k1=2.635 hour-1), $k_1^{\prime }$=0.1184 hour-1), A=0.1573, m=0.5465
Peak-bound intracellular model	(k1=2.635 hour-1), ($k_1^{\prime }$=0.1184 hour-1), k2=0.2024 hour-1,	k3=0.4707 hour-1, m=1.381	k1=0.3267 hour-1, $k_1^{\prime }$=0.02413 hour-1, k2=3.745 hour-1, k3=1.441 hour-1, m=1.956	(k1=2.635 hour-1), ($k_1^{\prime }$=0.1184 hour-1), k2/k3=0.02837, (k3=infinity), m=0.5715

Where units are not shown, concentrations are in micrograms per milliliter and time is in hours. Values in parentheses were determined from independent uptake data [2], or were chosen arbitrarily because they do not significantly affect the fit [3].

^*B represents the plateau value of survival (fraction of controls) in the high-concentration limit, and therefore cannot be less than 0. This constraint was included in the optimization process.