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. Author manuscript; available in PMC: 2006 Jul 14.
Published in final edited form as: Mol Endocrinol. 1997 Sep;11(10):1497–1506. doi: 10.1210/mend.11.10.9996

Fig. 4. A Variant Form of the CRE Is Repressed by AR.

Fig. 4

The CREs of the human α-subunit promoter were replaced with a variant form of the CRE that contains a C-to-T mutation in the core of each CRE (Var, TGACGTCA to TGATGTCA). Fifteen hundred base pairs of the human α-subunit promoter containing the variant CRE were used to drive expression of the luciferase reporter gene. The luciferase constructs were transfected into αT3 cells with RSV-β-galactosidase and either CMV-GH (black bars) or pCMVhAR (hatched bars). Transfections are as described in the legend of Fig. 2.