Table 2.

Chromosomal Instability in Clones Subjected to Chronic Oxidative Stress.

Treatment	Number of Clones	Number of Metaphase Subpopulations*	Percentage of Metaphases†
Controls	44	0–3	0–3
H2O2, 100 µm	31	0–2	0–5.5
	2	1–2	97–100
	6	3–4	1.5–3.5
	5	3–5	5–18
H2O2, 200 µm	35	0–4	0–3.5
	1	1	61
	7	3–5	6.5–10.5
	3	7–10	52–75
GO, 50 mU/ml	39	0–3	0–4
	7	3–6	5–23
	2	7–8	21–100

Boldface indicates chromosomally unstable clones, as defined by those clones containing three or more abnormal metaphase subpopulations comprising at least 5% of all metaphases scored.

^*Number of different abnormal metaphase subpopulations showing distinct types of chromosome aberrations.

^†Percentage of metaphases scored showing chromosomal aberrations.