The Hoxc8-regulated transcriptional network in vivo. Hoxc8 can regulate the cross-talk between Wnt, BMP, FGF signaling pathway by direct down-regulating Ncam, opn, pedf, and Zac1 and up-regulating Cdh11 in vivo. Direct pathways are indicated by solid lines and arrows, and indirect consequences of pathway activation and inactivation are indicated by dotted lines.