Table 1.

Effects of therapy with cytotoxic analogs of somatostatin (AN-238), LHRH (AN-207), bombesin (AN-215), and some combinations of these analogs as well as cytotoxic radical AN-201 on the growth of UCI-107, OV-1063, and ES-2 human ovarian carcinomas xenografted into nude mice

Experiment and cell line	Treatment	Initial tumor volume, mm3	Final tumor volume, mm3 (% inhibition)	Tumor weight, mg (% inhibition)	Tumor doubling time, days	WBC on day 8, cells per mm3	Deaths in experiment groups
UCI-107	Control	254.4 ± 56.0	3,350.8 ± 378.1	3,779.1 ± 377.0	5.9 ± 0.5	9,460 ± 1081	0
	AN-238	258.3 ± 43.0	2,020.8 ± 332.1 (43.1)**	2,192.3 ± 345.2 (42.0)**	8.0 ± 0.9*	8,332 ± 226	0
	AN-215	256.4 ± 51.4	2,248.1 ± 437.8 (36.7)*	2,391.1 ± 448.5 (36.7)*	7.2 ± 0.4	8,580 ± 486	0
	AN-215 + AN-238	246.5 ± 31.7	1,908.9 ± 380.7 (46.2)**	2,108.2 ± 381.5 (44.2)	9.9 ± 1.5*	8,415 ± 244	0
	AN-201	266.1 ± 115.3	4,037.2 ± 1,899.6 (+13.7)	4,471.6 ± 2,127.3 (18.3)	6.0 ± 0.9	5,720 ± 841*	0
OV-1063	Control	62.1 ± 16.1	3,460.0 ± 832	4,646.3 ± 1,665.2	4.4 ± 0.3	7,260 ± 389	0
	AN-238	54.8 ± 18.9	1,130.1 ± 427.7 (67.3)*	1,125.0 ± 305.9 (75.8)	9.5 ± 0.7	6,490 ± 444	2/9
	AN-238 + AN-207	51.7 ± 17.2	1,449.8 ± 526.1 (58.10)*	1,433.8 ± 489.0 (69.1)*	4.9 ± 0.3	6,682 ± 566	0
	AN-201	55.3 ± 15.1	1,979.5 ± 735.5 (42.8)	2,636.7 ± 1,148.8 (43.2)	5.0 ± 0.6	5,527 ± 197*	1/9
ES-2	Control	76.1 ± 16.1	316.6 ± 52.8	316.7 ± 51.2	11.9 ± 1.6	8,910 ± 548	0
	AN-238	72.1 ± 18.6	157.8 ± 30.2 (50.2)*	211.2 ± 38.5 (33.3)	26.6 ± 8.4*	7,122.5 ± 960	2/9
	AN-238 + AN-207	63 ± 14.4	147.4 ± 27.3 (53.5)**	235 ± 45.4 (25.79)	27.5 ± 7.8*	7205 ± 484	0
	AN-201	80.3 ± 14.0	291.8 ± 50.6 (7.9)	308.6 ± 44.3 (2.56)	13.8 ± 2.4	4372 ± 549**	1/9

WBC levels and animal deaths are shown in the last two columns.

*, P < 0.05;

**, P < 0.01; two-tailed Student’s t test).