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. 2006 Jun 27;103(27):10456–10460. doi: 10.1073/pnas.0603045103

Fig. 4.

Fig. 4.

Knockdown of ERα in the VMN inhibits estrogen-inducible female sexual behavior. Mice were primed with EB and tested with stud male mice 3 weeks (Experiment 1, n = 10 for each group) or 4 weeks (Experiment 2, n = 7 for AAV.H1.ER1 and n = 6 for AAV.H1.Luc) after stereotaxic virus injection. In both experiments, mice treated with AAV.H1.ER1 in the VMN did not show any receptive behaviors, i.e., proceptive postures (A) or lordosis (B) compared with the animals injected with AAV.H1.Luc. Instead, they showed vigorous rejection (such as kicking, fleeing, and upright posture) toward male approaches, attempted mounts, and mounts (C). ∗, P < 0.01. Data are presented as the mean ± SEM. Only the mice with bilateral VMN-specific knockdown of ERα were included in the analysis.