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Model for PKR activation. The intramolecular inhibitory interaction between the PBM (residues 328–335 of PKR, represented as Δ) in the KD and dsRBM2 maintains PKR in an inactive conformation. Binding of dsRNA to dsRBM1 and dsRBM2 or binding of PACT domain 3 to PBM disrupts the intramolecular interaction in latent PKR and induces similar conformational changes leading to its activation.
