Fig. 4.

Coumarins bind to a region that may disrupt formation of active IN multimers. Shown are symmetric dimers with a tetrameric arrangement for a catalytically functional IN core domain. Compound 3 is shown in white ball and stick, the side chains of the ¹²⁸AACWWAGIK¹³⁶ residues are shown as green stick, the magenta and yellow ribbon shows two IN monomers, whereas red sticks and brown spheres represent the conserved DDE motif and Mg²⁺ ion, respectively.