Table 1.

Relative activities of integrase proteins

IN protein	3′-Processing*	Strand transfer*
SolMut†	+++	+++
C130A	+++	+++
C130S	+++	+
W131G	++	++
W132A	+++	−
W132G	+++	−
W132R	+++	−
W132Y	+++	++
K136R	+++	++
Q148A	+	+

*Activity designation relative to WT: −, 0–10%; +, 10–40%; ++, 40–80%; +++, 80–100%.

^†F185K/C280S soluble double mutant.