Table 4.

Effect of Topical Application of EGCG in Hydrophilic Cream on Bone Mineral Density, Bone Mineral Content, Lean Mass and Fat in Mice^*.

Treatment Group	TBMD (mg/cm2)	TBMC (mg)	Lean (g)	Fat (g)
Control (non-EGCG)	65 ± 4†	582 ± 13	19.9 ± 1.9	5.3 ± 1.3
EGCG alone	61 ± 2	561 ± 33	20.3 ± 1.7	4.2 ± 0.8(21)‡
UVB alone	57 ± 4	539 ± 57	20.4 ± 2.4	5.3 ± 1.2
EGCG + UVB	60 ± 3	542 ± 47	20.9 ± 1.4	4.0 ± 0.9(25)§

The values in parentheses indicate percent reduction in fat content by EGCG treatment.

^*Photocarcinogenesis experiment was continued for 30 weeks. At the end of the experiment, mice were sacrificed and subjected to DXA analysis. A brief description of analysis is described in Materials and Methods section. Each treatment group contained 20 mice. TBMD = total bone mineral density (bone mineral content/bone area); TBMC = total bone mineral content.

^†Data are expressed as mean ± SD from 20 animals in each group.

^‡Significant reduction in fat content, EGCG alone versus non-EGCG treatment (P < .05).

^§Significant reduction in fat content, EGCG + UVB versus UVB alone (P < .05).