Table 7.
A. pernix proteins conserved in a wide range of organisms but missing in euryarchaea (examples)
| A. pernix gene/COG number | Phylogenetic pattern* | Function | Comments | |
| APE1618/1048 | - - - - -zyq-d-ebr- - - - - - - - - -x | Aconitase A | Unlike other archaea with sequenced genomes, A. pernix is an aerobe and possesses the complete TCA cycle. APE1618 belongs to a distinct family of (otherwise) bacterial aconitases (e.g E. coli AcnA and B. subtilis CitB). APE1816 also belongs to a specific family of bacterial fumarases. | |
| APE1816/0114 | - - - - -zy- -dcebrhu- - - - - -i-x | Fumarase | ||
| APE1677/1071 | - - - - -zy- -dc-br- - - -gp- -i-x | pyruvate dehydrogenase E1 component, α-subunit | ||
| APE1674/0022 | - - - - -zy- -dc-br- - - -gp- -i-x | pyruvate dehydrogenase E1 component, β-subunit | ||
| APE1671/0508 | - - - - -zy- -dcebrh- - -gp- -i-x | Dihydrolipoamide acyltransferase | ||
| APE1725/1290 | - - - - -z-q-dc-br-uj- - - - - -nx | Cytochrome b | As an aerobe, A. pernix encodes specific electron-transport chain components. APE1623 is closely related to the ortholog from Aquifex aeolicus. | |
| APE1623, APE0793_1/0843 | - - - - -z-q-dcebr-uj- - - - - -nx | Cytochrome c oxidase, heme b and copper-binding subunit | ||
| APE0793_2/ | - - - - -z-q-dcebr- - - - - - - - - -x | Cytochrome oxidase, subunit 3 | ||
| 1845 | ||||
| APE1498/1171 | - - - - -zy-vdcebrh- - - - - - - - -x | Threonine dehydratase | Specifically related to a subfamily of bacterial catabolic threonine dehydratases (e.g. E. coli TdcB) | |
| APE1038/0295 | - - - - -zy-vd-ebrh- -wgpo- - - - | Cytidine deaminase | ||
| APE1353/0514 | - - - - -zy-dceb-h- - - - - -l- - - | DNA helicase (RecQ family) | APE1353 differs from other members of the RecQ family by the presence of long amino-terminal extension that probably form a non-globular domain. APE1353 shows no specific affinity to any of the bacterial orthologs. | |
| APE2450/0260 | - - - - -z-q-dcebrhu-wgp- -i-x | Leucyl aminopeptidase | ||
| APE0137/0405 | - - - - -zy- -dcebr-u- - - - - - - - - | Gamma-glutamyltranspeptidase | ||
| APE2464/ | - - - - -z-qvdcebr- - - - - - - - - - - | Phosphate starvation-inducible protein | ||
| COG1702 | PhoH, Predicted ATPase | |||
| APE0993/>0813 | - - - - -z- - -d-eb-hu-wgp-l- - - | Purine-nucleoside phosphorylase | Correlates with the absence of de novo purine biosynthesis and the probable importance of salvage pathways | |
| APE2105/0813a | - - - - -z- - - - - -e- -h- - - - -l- - - | Uridine phosphorylase | ||
| APE0033/1866 | - - - - -zy- -d-eb-h- - - - - - - - - - | Phosphoenolpyruvate carboxykinase |
*The designations are as in Table 6.