TABLE 2.
In vitro susceptibility of uncommon Candida spp. to voriconazole determined by BMD and Etest
| Species (no. of isolates tested) | Test method | Cumulative no. of isolates (%) susceptible at MIC (μg/ml):
|
% Agreementa | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.07 | 0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | |||
| C. krusei (118) | BMD | 0 | 0 | 0 | 1 (1) | 13 (11) | 62 (53) | 110 (93) | 116 (98) | 118 (100) | |||
| Etest | 0 | 0 | 0 | 4 (3) | 16 (14) | 84 (71) | 113 (96) | 117 (99) | 117 (99) | 118 (100) | 99 (117/118) | ||
| C. lusitaniae (56) | BMD | 38 (68) | 51 (91) | 53 (95) | 53 (95) | 53 (95) | 54 (96) | 56 (100) | |||||
| Etest | 37 (66) | 51 (91) | 52 (93) | 53 (95) | 53 (95) | 54 (96) | 56 (100) | 100 (56/56) | |||||
| C. guilliermondii (53) | BMD | 3 (6) | 5 (9) | 10 (19) | 27 (51) | 35 (66) | 43 (81) | 49 (92) | 49 (92) | 51 (96) | 51 (96) | 51 (96) | |
| Etest | 7 (13) | 12 (23) | 28 (53) | 46 (87) | 49 (92) | 51 (96) | 52 (98) | 53 (100) | 79 (42/53) | ||||
| C. kefyr (11) | BMD | 4 (36) | 8 (73) | 11 (100) | |||||||||
| Etest | 0 | 6 (55) | 11 (100) | 100 (11/11) | |||||||||
| C. rugosa (10) | BMD | 1 (10) | 2 (20) | 3 (30) | 6 (60) | 7 (70) | 10 (100) | ||||||
| Etest | 1 (10) | 4 (40) | 7 (70) | 7 (70) | 9 (90) | 10 (100) | 100 (10/10) | ||||||
| C. lipolytica (8) | BMD | 0 | 0 | 1 (13) | 3 (38) | 6 (75) | 6 (75) | 6 (75) | 7 (88) | 7 (88) | 8 (100) | ||
| Etest | 0 | 1 (13) | 4 (50) | 6 (75) | 6 (75) | 6 (75) | 7 (88) | 7 (88) | 7 (88) | 7 (88) | 7 (88) | 100 (8/8) | |
| C. pelliculosa (8) | BMD | 0 | 0 | 0 | 0 | 4 (50) | 8 (100) | ||||||
| Etest | 0 | 1 (13) | 4 (50) | 6 (75) | 6 (75) | 6 (75) | 7 (88) | 7 (88) | 7 (88) | 7 (88) | 7 (88) | 100 (8/8) | |
| C. pelliculosa (8) | BMD | 0 | 0 | 0 | 0 | 4 (50) | 8 (100) | ||||||
| Etest | 0 | 1 (13) | 2 (25) | 3 (38) | 5 (63) | 8 (100) | 88 (7/8) | ||||||
| C. dubliniensis (7) | BMD | 6 (86) | 7 (100) | ||||||||||
| Etest | 7 (100) | 100 (7/7) | |||||||||||
| C. famata (3) | BMD | 1 (33) | 1 (33) | 2 (67) | 2 (67) | 2 (67) | 3 (100) | ||||||
| Etest | 2 (67) | 2 (67) | 3 (100) | 67 (2/3) | |||||||||
| C. zeylanoides (3) | BMD | 2 (67) | 2 (67) | 2 (67) | 2 (67) | 3 (100) | |||||||
| Etest | 2 (67) | 2 (67) | 3 (100) | 100 (3/3) | |||||||||
| C. inconspicua (1) | BMD | 0 | 0 | 0 | 0 | 1 (100) | |||||||
| Etest | 0 | 0 | 1 (100) | 100 (1/1) | |||||||||
| C. norvegensis (1) | BMD | 0 | 0 | 0 | 0 | 1 (100) | |||||||
| Etest | 0 | 0 | 0 | 0 | 0 | 1 (100) | 100 (1/1) | ||||||
| All species (279) | BMD | 55 (20) | 76 (27) | 89 (32) | 112 (40) | 143 (51) | 209 (75) | 265 (95) | 272 (97) | 276 (99) | 277 (99) | 277 (99) | |
| Etest | 62 (22) | 91 (33) | 118 (42) | 144 (52) | 163 (58) | 239 (86) | 272 (97) | 277 (99) | 277 (99) | 278 (99) | 278 (99) | 95 (265/279) | |
a
% agreement signifies the percentage of Etest MICs within 2 dilutions of the reference BMD MICs determined following 48 h of incubation.