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Mutants of PSSO that reach the interior of vacuoles. PCR-generated mutants were transformed into yeast, and cells from individual colonies were screened by fluorescence microscopy. (A) Sequence changes in the mutants. (B) Confocal images of cells grown to exponential phase in liquid culture (only vacuoles are visible). Note that under these conditions, only mutant p2.1-26 retains a strong internalization phenotype.
