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Role of TNF receptors in the synergistic activity of NGR-mTNF and melphalan. (a) Effect of mAb V1q (an anti-mTNF neutralizing antibody) on the antitumor activity of melphalan in combination with NGR-mTNF in the B16F1 model. The drugs were administered at day 5. V1q and NGR-mTNF were premixed and incubated for 1 hour before injection into animals. (b) Effect of melphalan in combination with NGR-hTNF at the indicated doses.
