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Alignment of TrpEa from S. typhimurium with TrpEa proteins restricted to co-function with a TrpEb_2 type of β subunit. Catalytic residues Sty E49 and D60, as well as other conserved residues shown to be important for indoleglycerol phosphate binding are shown in blue. Other invariant (highlighted) or near-invariant (shaded) residues are marked in yellow. Conserved residues that important for intersubunit signaling with TrpEb_1 are shown in green.
