Abstract
The effects of partially purified human leucocyte interferon (PIF) and of a preparation purified by passage twice through a monoclonal antibody affinity chromatography column (NK21F) were compared with those of a control solution in healhty volunteers. After intramuscular injections both interferon preparations caused rises in pulse rate and body temperature, changes in circulating white cell counts, and various unpleasant symptoms, the most common of which were headache, malaise, and fever. Slightly lower doses of NK21F were given, and this was reflected in lower peak serum concentrations. Mean symptom scores, however, were not lower after NK21F than after PIF. Local inflammatory reactions eight hours after intradermal inoculations of these interferons were similar. Purification of interferon using a monoclonal antibody does not reduce the facets of its activity considered in this study. They are therefore inherent in the leucocyte interferon type selected by the antibody.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Atherton K. T., Burke D. C. Interferon induction by viruses and polynucleotides: a differential effect of comptothecin. J Gen Virol. 1975 Dec;29(3):297–304. doi: 10.1099/0022-1317-29-3-297. [DOI] [PubMed] [Google Scholar]
- Cantell K., Hirvonen S. Large-scale production of human leukocyte interferon containing 10(8) units per ml. J Gen Virol. 1978 Jun;39(3):541–543. doi: 10.1099/0022-1317-39-3-541. [DOI] [PubMed] [Google Scholar]
- Hayes T. G., Yip Y. K., Vilcek J. Le interferon production by human fibroblasts. Virology. 1979 Oct 30;98(2):351–363. doi: 10.1016/0042-6822(79)90558-0. [DOI] [PubMed] [Google Scholar]
- Ingimarsson S., Cantell K., Strander H. Side effects of long-term treatment with human leukocyte interferon. J Infect Dis. 1979 Oct;140(4):560–563. doi: 10.1093/infdis/140.4.560. [DOI] [PubMed] [Google Scholar]
- Karmazyn M., Horrobin D. F., Manku M. S., Karmali R. A., Morgan R. O., Ally A. I., Cunnane S. C. Interferon fever. Lancet. 1977 Aug 6;2(8032):307–307. doi: 10.1016/s0140-6736(77)90999-0. [DOI] [PubMed] [Google Scholar]
- Priestman T. J. Initial evaluation of human lymphoblastoid interferon in patients with advanced malignant disease. Lancet. 1980 Jul 19;2(8186):113–118. doi: 10.1016/s0140-6736(80)90004-5. [DOI] [PubMed] [Google Scholar]
- Scott G. M., Stewart W. E., 2nd, Tyrrell D. A., Cantell K., Cartwright T., Edy V. G. Skin reactions to interferon inoculations are reduced but not abolished by purification. J Interferon Res. 1980 Fall;1(1):79–86. doi: 10.1089/jir.1980.1.79. [DOI] [PubMed] [Google Scholar]
- Scott G. M., Tyrrell D. A. Interferon: therapeutic fact or fiction for the '80s? Br Med J. 1980 Jun 28;280(6231):1558–1562. doi: 10.1136/bmj.280.6231.1558. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Secher D. S., Burke D. C. A monoclonal antibody for large-scale purification of human leukocyte interferon. Nature. 1980 Jun 12;285(5765):446–450. doi: 10.1038/285446a0. [DOI] [PubMed] [Google Scholar]
- Sikora K. Does interferon cure cancer? Br Med J. 1980 Sep 27;281(6244):855–858. doi: 10.1136/bmj.281.6244.855. [DOI] [PMC free article] [PubMed] [Google Scholar]