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. 2001 Jan;3(1):62–69. doi: 10.1038/sj.neo.7900125

Figure 2.

Figure 2

Evidence of a CIN-like process in DU145 cells as shown by structural and numerical aberrations. Panels A, B, C: Representative marker chromosomes observed in parental DU145 cell line [der( 14) t(3; 14); der(Y) t(Y;20); der(13)t(2;13)], and putative structural derivatives thereof (clonal and nonclonal) in the parental and subclone cell lines. Note the maintenance of the original marker chromosome in each of the structural derivatives and progression from a simple to a more complex rearrangement, suggestive of marker evolution. Panels D, E: Representative metaphase (Panel D) and interphase nuclei (Panel E) FISH image using centromere 8 probe (green) from the DU145 parental cell line. Analysis on a cell-by-cell basis revealed frequent chromosome 8 copy number change in a subpopulation of DU145 cells.