Table 1.
Proteins encoded by genes directly targeted by HIF-1α
| Role | Protein |
| Glucose/energy metabolism Cell proliferation/viability | Adenylate kinase 3 |
| Aldolase a | |
| Aldolase c | |
| Enolase-1 | |
| Glucose transporter 1 | |
| Glucose transporter 3 | |
| Glyceraldehyde-3-phosphate dehydrogenase | |
| Hexokinase 1 | |
| Hexokinase 2 | |
| Insulin-like growth factor (IGF)-2 | |
| IGF-binding protein (IGFBP)-1 | |
| IGFBP-3 | |
| Lactate dehydrogenase a | |
| Phosphoglycerate kinase 1 | |
| Pyruvate kinase m | |
| p21 | |
| Transforming growth factor | |
| Erythropoiesis Iron metabolism | Ceruloplasmin |
| Erythropoietin | |
| Transferring | |
| Transferrin receptor | |
| Vascular development/remodelling Vasomotor tone | Adrenergic receptor |
| Adrenomedullin | |
| Endothelin-1 | |
| Heme oxygenase-1 | |
| Nitric oxide synthase 2 | |
| Plasminogen activator inhibitor 1 | |
| Vascular endothelial growth factor (VEGF) | |
| VEGF receptor FLT-1 |