FIG. 2.

Ribbon representation of models of M. tuberculosis MscL in a closed (left), an intermediate (middle), and an open (right) conformation shown as viewed from outside the cell (top row) and from the side (bottom). Only one subunit is colored in the side view, so that the conformation of a single subunit can be visualized. Structural models of the MscL proteins have been developed in 13 different conformations with different size transmembrane pores. Three of these conformations are illustrated here. The color code is as follows: N, red; MI, orange; Loop, yellow; M2, light blue; Linker, aqua blue; S, dark blue. (Modified with permission from reference 49.)