TABLE 2.
Sequenced proteins of the MscS family
| Abbreviation | Database description | Organism | Sized | gie number |
|---|---|---|---|---|
| Archaea | ||||
| Ape1 | Hypothetical protein APE1441 | Aeropyrum pernix | 285 | 7444698 |
| Ape2 | Hypothetical protein APE1867 | Aeropyrum pernix | 295 | 7516782 |
| Ape3 | Hypothetical protein APE2455 | Aeropyrum pernix | 283 | 7517184 |
| Afu | Hypothetical protein AF1546 | Archaeoglobus fulgidus | 283 | 11499141 |
| Hsp1 | Vng1164c | Halobacterium sp. strain NRC-1 | 300 | 10580699 |
| Hsp2 | Vng2113c | Halobacterium sp. strain NRC-1 | 274 | 10581527 |
| Hsp3c | Vng1388h | Halobacterium sp. strain NRC-1 | 259 | 10580895 |
| Mja1 | Hypothetical protein MJ0170 | Methanococcus jannaschii | 350 | 2501530 |
| Mja2 | Hypothetical protein MJ1143 | Methanococcus jannaschii | 361 | 2501531 |
| Mja3 | Hypothetical protein MJ0700 | Methanococcus jannaschii | 324 | 2833543 |
| Mth | Conserved hypothetical protein MTH1830 | Methanobacterium thermoautotrophicum | 248 | 7482176 |
| Pab | Hypothetical protein PAB1281 | Pyrococcus abyssi | 346 | 14521824 |
| Pho | Hypothetical protein PH0336 | Pyrococcus horikoshii | 335 | 7518590 |
| Sso1 | Conserved hypothetical protein SSO2769 | Sulfolobus solfataricus | 308 | 13816106 |
| Sso2 | Conserved hypothetical protein SSO2829 | Sulfolobus solfataricus | 291 | 13816184 |
| Sso3c | Hypothetical protein SSO0550 | Sulfolobus solfataricus | 314 | 6015922 |
| Sso4a | Hypothetical protein SSO2786 | Sulfolobus solfataricus | 205 | 13816129 |
| Tac1 | Conserved hypothetical membrane protein Ta0796 | Thermoplasma acidophilum | 286 | 10640074 |
| Tac2 | Conserved hypothetical membrane protein Ta0909 | Thermoplasma acidophilum | 297 | 10640186 |
| Tvo1 | Small-conductance MS channel TVN0705 | Thermoplasma volcanium | 288 | 13541536 |
| Tvo2 | Small-conductance MS channel TVN0821 | Thermoplasma volcanium | 297 | 13541652 |
| Gram-negative bacteria | ||||
| Aae1 | Hypothetical protein AQ_812 | Aquifex aeolicus | 368 | 6136577 |
| Aae2 | Conserved hypothetical protein AQ_1013 | Aquifex aeolicus | 436 | 7514431 |
| Bbu | Conserved hypothetical protein BB0453 | Borrelia burgderi | 280 | 7444701 |
| Bsp | Hypothetical protein BU452 | Buchnera sp. strain APS | 305 | 11387303 |
| Bma | YggB protein | Burkholderia mallei | 290 | 13446682 |
| Bps | YggB protein | Burkholderia pseudomallei | 271 | 13932325 |
| Cje1 | Probable integral membrane protein Cj0238 | Campylobacter jejuni | 627 | 11346911 |
| Cje2 | Probable membrane protein Cj1007c | Campylobacter jejuni | 523 | 11282200 |
| Ccr1 | Conserved hypothetical protein CC3612 | Caulobacter crescentus | 328 | 13425360 |
| Ccr2 | Conserved hypothetical protein CC3000 | Caulobacter crescentus | 341 | 13424636 |
| Ctea | AefA protein (fragment) | Chlorobium tepidum | 230 | 10198122 |
| Eic | Hypothetical 30.6-kDa protein | Edwardsiella ictaluri | 286 | 6686193 |
| KefA (Eco) | Potassium efflux system KefA | Escherichia coli | 1120 | 2501527 |
| YggB (Eco2) | Hypothetical 30.9-kDa protein | Escherichia coli | 286 | 140687 |
| YjeP (Eco3) | Hypothetical 123.8-kDa protein | Escherichia coli | 1107 | 2851660 |
| Eco4 | Hypothetical 38.8-kDa protein | Escherichia coli | 343 | 6176597 |
| YbiO (Eco5) | Hypothetical 81.9-kDa protein | Escherichia coli | 741 | 3915948 |
| Eco6 | Hypothetical 46.6-kDa protein | Escherichia coli | 415 | 2506616 |
| Hin | Protein HI0195.1 precursor | Haemophilus influenzae | 1111 | 2501528 |
| Hpy1 | Hypothetical integral membrane protein HP0983 | Helicobacter pylori | 274 | 7444700 |
| Hpy2 | Hypothetical integral membrane protein HP0284 | Helicobacter pylori | 523 | 7463934 |
| Hpy3 | Hypothetical protein HP0415 | Helicobacter pylori | 623 | 6136524 |
| Mlo1 | Hypothetical protein mll1272 | Mesorhizobium loti | 850 | 13471329 |
| Mlo2 | Hypothetical protein mlr4006 | Mesorhizobium loti | 283 | 13473416 |
| Mlo3 | Hypothetical proteins mll3287 | Mesorhizobium loti | 739 | 13472860 |
| Mlo4c | Probable integral membrane protein mlr0973 | Mesorhizobium loti | 410 | 13471089 |
| Nme1 | Conserved hypothetical protein NMB0042 | Neisseria meningitidis MC58 | 282 | 11278435 |
| Nme2 | Hypothetical protein NMB0213 | Neisseria meningitidis MC58 | 328 | 11282692 |
| Neua | ORF2 (fragment) | Nitrosomonas europaea | 109 | 3777488 |
| Pmu | Unknown | Pasteurella multocida | 1113 | 12720603 |
| Pch1 | BspA protein | Pectobacterium chrysanthemi | 1106 | 11691630 |
| Pch2a | Hypothetical protein; BspB (fragment) | Pectobacterium chrysanthemi | 999 | 15027208 |
| Pae1 | Conserved hypothetical protein PA5022 | Pseudomonas aeruginosa | 1118 | 11348278 |
| Pae2 | Conserved hypothetical protein PA4394 | Pseudomonas aeruginosa | 278 | 11348170 |
| Pae3 | Conserved hypothetical protein PA4925 | Pseudomonas aeruginosa | 283 | 11348259 |
| Pae4 | Hypothetical protein PA1408 | Pseudomonas aeruginosa | 807 | 11349198 |
| Pae5 | Hypothetical protein PA5121 | Pseudomonas aeruginosa | 735 | 11350368 |
| Pae6 | Conserved hypothetical protein PA3468 | Pseudomonas aeruginosa | 442 | 11348032 |
| Pae7c | Conserved hypothetical protein PA1775 | Pseudomonas aeruginosa | 274 | 11347832 |
| Pae8c | Hypothetical protein PA5251 | Pseudomonas aeruginosa | 192 | 11350399 |
| Pfl | CmpX | Pseudomonas fluorescens | 274 | 5668604 |
| Rpr | Hypothetical protein RP047 | Rickettsia prowazekii | 388 | 7467637 |
| Styc | Hypothetical protein | Salmonella enterica serova Typhimurium | 377 | 2337947 |
| Sme1 | Conserved hypothetical protein SMa1582 | Sinorhizobium meliloti | 432 | 14523992/PICK> |
| Sme2a | Conserved hypothetical membrane protein SMa0630 | Sinorhizobium meliloti | 523 | 14523416 |
| Sme3 | Conserved hypothetical protein SMa0937 | Sinorhizobium meliloti | 719 | 14523607 |
| Sme4b | Hypothetical protein SMa1678 (partial homologue) | Sinorhizobium meliloti | 93 | 14524059 |
| Ssp1 | Hypothetical 33.2-kDa protein slr0639 | Synechocystis sp. strain PCC6803 | 296 | 2501529 |
| Ssp2 | Hypothetical protein slr1575 | Synechocystis sp. strain PCC6803 | 479 | 7469751 |
| Ssp3 | Hypothetical protein slr0510 | Synechocystis sp. strain PCC6803 | 505 | 7469671 |
| Ssp4 | Hypothetical protein sll0985 | Synechocystis sp. strain PCC6803 | 704 | 7469967 |
| Ssp5 | Hypothetical protein slr0765 | Synechocystis sp. strain PCC6803 | 617 | 7470274 |
| Ssp6 | Hypothetical protein sll1040 | Synechocystis sp. strain PCC6803 | 765 | 7469981 |
| Ssp7 | Hypothetical protein slr0109 | Synechocystis sp. strain PCC6803 | 318 | 7469704 |
| Ssp8c | Hypothetical protein sll0590 | Synechocystis sp. strain PCC6803 | 564 | 7469688 |
| Tma | Conserved hypothetical protein TM1563 | Thermotoga maritima | 268 | 7444699 |
| Tpa | Conserved hypothetical protein TP0822 | Treponema pallidum | 301 | 7514621 |
| Vch1 | Conserved hypothetical protein VC0480 | Vibrio cholerae | 287 | 11278432 |
| Vch2 | Conserved hypothetical protein VC1751 | Vibrio cholerae | 292 | 11278433 |
| Vch3 | Conserved hypothetical protein VC0265 | Vibrio cholerae | 412 | 11354507 |
| Vch4 | Hypothetical protein VCA0817 | Vibrio cholerae | 194 | 11345735 |
| Vch5 | Hypothetical protein VCA0181 | Vibrio cholerae | 291 | 11355375 |
| Xfa1 | Small-conductance MS ion channel XF1258 | Xylella fastidiosa | 305 | 11362678 |
| Xfa2 | Conserved hypothetical protein XF0437 | Xylella fastidiosa | 431 | 11360698 |
| Zmo1 | Hypothetical protein | Zymomonas mobilis | 618 | 5354203 |
| Zmo2c | Unknown | Zymomonas mobilis | 376 | 4378179 |
| Gram-positive bacteria | ||||
| Bha1 | BH2683, unknown conserved protein | Bacillus halodurans | 379 | 10175304 |
| Bha2 | BH2666, unknown conserved protein | Bacillus halodurans | 276 | 10175287 |
| Bsu1 | Hypothetical 42.5-kDa protein | Bacillus subtilis | 371 | 6136721 |
| Bsu2 | Conserved hypothetical protein YkuT | Bacillus subtilis | 267 | 7474634 |
| Bsu3 | Conserved hypothetical protein YfkC | Bacillus subtilis | 280 | 14523156 |
| Dra1 | Conserved hypothetical protein DR0211 | Deinococcus radiodurans | 368 | 7471627 |
| Dra2 | Conserved hypothetical protein DR1995 | Deinococcus radiodurans | 426 | 7471720 |
| Lla | Conserved hypothetical protein YncB | Lactococcus lactis | 248 | 12724266 |
| Mtu1b,c | Cyclic nucleotide-binding protein Rv2434c | Mycobacterium tuberculosis | 481 | 7478360 |
| Mtu2 | Hypothetical protein Rv3104c | Mycobacterium tuberculosis | 308 | 7477495 |
| Sau | Conserved hypothetical protein SAV0361 | Staphylococcus aureus | 293 | 13700275 |
| Spn | MS ion channel SP1752 | Streptococcus pneumoniae | 201 | 14973248 |
| Spy | Conserved hypothetical protein SPy1897 | Streptococcus pyogenes | 281 | 13622927 |
| Sco1 | Hypothetical protein SCF43A.26c | Streptomyces coelicolor | 333 | 7479987 |
| Sco2 | Putative membrane protein SC8E4A.26 | Streptomyces coelicolor | 408 | 6900955 |
| Sco3 | Probable membrane protein SC4A10.03 | Streptomyces coelicolor | 382 | 7480980 |
| Sco4c | Putative integral membrane protein SC8F11.27c | Streptomyces coelicolor | 353 | 7649646 |
| Eukaryotes | ||||
| Ath1c | Unknown protein | Arabidopsis thaliana | 676 | 12321837 |
| Ath2 | Similarity to putative protein T30F21.6 | Arabidopsis thaliana | 881 | 8671879 |
| Ath3 | Hypothetical protein | Arabidopsis thaliana | 856 | 4836872 |
| Ath4 | Hypothetical protein | Arabidopsis thaliana | 849 | 6598357 |
| Ath5 | Hypothetical protein F14F18.230 | Arabidopsis thaliana | 734 | 11357421 |
| Ath6 | GblAAD30575.1 ∼gene_id:T21E2.7∼ | Arabidopsis thaliana | 881 | 11994592 |
| Ath7a | Hypothetical protein | Arabidopsis thaliana | 698 | 6598358 |
| Ath8 | Hypothetical protein F12B17.160 | Arabidopsis thaliana | 447 | 7474572 |
| Ath9 | Hypothetical protein A_IG005I10.9 (partial homologue) | Arabidopsis thaliana | 353 | 7485270 |
| Ath10c | Hypothetical protein F12B17.160 | Arabidopsis thaliana | 477 | 11357358 |
| Spo1 | Conserved hypothetical protein SPAC2C4.17c | Schizosaccharomyces pombe | 840 | 7490286 |
| Spo2 | Hypothetical protein SPCC1183.11 | Schizosaccharomyces pombe | 1011 | 7491774 |
a
These proteins are thought to be fragments and therefore were not included in the study reported in Table 3.
b
These proteins were more divergent in sequence than the other homologues and were therefore omitted from our study.
c
These proteins were omitted from Fig. 11 (see our ALIGN website) because the conserved motif could not be established throughout their sequences.
d
Number of amino acids.
e
gi, GenBank index.