C4 phenotypes based on allotyping of the patient (Pa), sister (Si), control (Co), father (Fa), brother (Br), and mother (Mo). The C4 concentrations for the patient, sister, father, brother, and mother were 0.16, 0.29, 0.22, 0.16, and 0.18 g/liter, respectively, corresponding to the absence of C4B protein in the patient, brother, and mother.