Table 1.

Inhibition of Angiogenesis and Human KM12L4 Colon Cancer in Nude Mice by IFN-α.

IFN-α Treatment*		Liver Metastasis		Serum bFGF (pg/ml)†	Microvessel Density‡
Dose (Units)	Schedule	Incidence§	Liver wt (g) Mean±SD
Saline	Daily	9/10	1.74±0.2	206	59±4
70,000	1xweek	9/10	1.45±0.4	232	51±6
35,000	2xweek	8/10	1.37±0.2	175	53±3
10,000	Daily	1/10¶	1.2±0.2¶	141	35±3¶

^*KM12L4 cells (1x10⁶) were injected into the spleen of nude mice. Therapy began on day 7. Mice were euthanized on day 42.

^†Determined by ELISA.

^‡Microvessel density was determined by identifying tumor areas showing the most intense CD-31 staining. Mean number of vessels±SD per 20 100xfields.

^§Number of tumor-positive mice/number of mice injected.

^¶P<.01 versus control.