Table 2.

Systemic Administration of IFN-α-2a to Treat KM12L4 IFN^R Liver Metastasis in Nude Mice.

IFN-α Treatment*	Liver Metastasis		Liver wt (g) Mean±SD	Serum bFGF† (pg/ml)	Microvessel Density‡
	Median	Range
Saline	38	3–100	2.4±0.4	482	73±4
1000 U	12	0–50	1.7±0.2	303	58±3
10,000 U	0	0–15§	1.4±0.1¶	156¶	52±6¶

^*KM12L4 IFN^R cells (1x10⁶) were injected into the spleen of nude mice. Daily s.c. injections of saline or IFN-α-2a began on day 7. Mice were euthanized on day 42.

^†Determined by ELISA.

^‡Microvessel density was determined by identifying tumor areas showing the most intense CD-31 staining. Mean number of vessels±SD

^§P<.001 versus control.

^¶P<.01 versus control.