Table 1.
(A) Vascular Volume and (B) Permeability Data Summarized for the Six Tumor Models.
| (A) Vascular Volume Data Summarized for the Six Tumor Models | |||||||
| Cancer Model | Highest 10% Values of Histogram (“Highest”) | Highest 25% Values of Histogram (“High”) | All Nonzero Values of Histogram | ||||
| Breast | Tumor Volume (mm3) | % Volume | Mean Value (µl/g) | % Volume | Mean Value (µl/g) | % Volume | Mean Value (µl/g) |
| MDA-MB-435 (n=8) | 212±31 | 8.2±0.4 | 67.7±12.4* | 20.4±0.9 | 45.6±7.0* | 81.3±3.6 | 18.4±3.1 |
| MDA-MB-231 (n=4) | 287±62 | 8.6±0.4 | 36.8±5.2 | 21.3±1.0 | 27.2±3.7 | 85.1±3.8 | 11.0±2.7 |
| MCF-7 (n=6) | 270±44 | 8.8±0.5 | 32.7±4.8 | 22.1±1.2 | 24.5±3.4 | 88.1±4.9 | 12.5±2.5 |
| Prostate | % Volume | Value in µl/g | % Volume | Value in µl/g | % Volume | Value in µl/g | |
| MatLyLu (n=7) | 241±37 | 9.2±0.2† | 45.4±4.9‡ | 23±0.6† | 34.1±3.1†‡ | 91.3±2.4† | 19.0±1.8†‡ |
| PC-3 (n=5) | 310±60 | 6.5±0.6‡ | 36.4±3.4 | 16.2±1.5‡ | 21.7±1.2‡ | 63.8±6.2‡ | 6.7±0.8‡ |
| DU-145 (n=6) | 289±49 | 9.0±0.2 | 34.0±1.7 | 22.5±0.5 | 26.4±1.1 | 89.5 ±1.8 | 13.1 ±0.6 |
| (B) Permeability Data Summarized for the Six Tumor Models | |||||||
| Breast | % Volume | Mean Value (µl/g · min) | % Volume | Mean Value (µl/g · min) | % Volume | Mean Value (µl/g · min) | |
| MDA-MB-435 (n=8) | 212±31 | 7.5±0.8 | 4.2±0.6* | 19.0±2.1 | 2.6±0.3* | 74.6±8.2 | 0.19±0.1* |
| MDA-MB-231 (n=4) | 287±62 | 9.2±0.2* | 3.5±1.1* | 23.0±0.5* | 2.4±0.7* | 91.3±1.8* | 1.24±0.4* |
| MCF-7 (n=6) | 270±44 | 7.6±0.6 | 1.5±0.3 | 91.0±1.5 | 1.1±0.2 | 75.4±6.1 | 0.5±0.1 |
| Prostate | % Volume | Value in (µl/g · min) | % Volume | Value in (µl/g · min) | % Volume | Value in (µl/g · min) | |
| MatLyLu (n=7) | 241±37 | 9.2±0.1†‡ | 2.9±0.5† | 23±0.4†‡ | 2.2±0.3† | 91.0±1.5†‡ | 1.1±0.1†‡ |
| PC-3 (n=5) | 310±60 | 3.7±1.1‡ | 1.3±0.2 | 9.3±2.8‡ | 0.8±0.15 | 36.6±11‡ | 0.26±0.06‡ |
| DU-145 (n=6) | 289±49 | 8.0±0.3 | 2.1±0.5 | 20.0±0.8 | 1.5±0.3 | 79.1±3.3 | 0.6±0.1 |
Nonzero values and the corresponding regions represent values with detectable levels of albumin-GdDTPA where the pattern of enhancement followed the algorithm used to derive vascular volume and permeability.
Values are mean ± 1 SEM; n represents the number of tumors studied per model with at least four to six slices per tumor.
*
Significantly different from MCF-7.
†
Significantly different from PC-3.
‡
Significantly different from DU-145.