Table 1.
FISH Signals per Nucleus for Chromosome 7 in Samples of Different Tissue Types.
| Diagnosis | Case no. | Signals per nucleus (%) | |||||||||
| 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | >5 | ||
| Controls | |||||||||||
| Muscle | 249 | 3.0 | 9.0 | 81.0 | 4.0 | 1.0 | 0.0 | ND | 2.0 | ||
| Normal skin | 235 | 0.0 | 4.0 | 91.0 | 4.0 | 1.0 | 0.0 | 0.0 | 0.0 | ||
| Mucous membrane | 233 | 3.8 | 6.7 | 83.7 | 4.8 | 1.0 | 0.0 | 0.0 | 0.0 | ||
| Unaffected tissue | 305 | 3.0 | 13.0 | 81.0 | 3.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| Unaffected tissue | 312 | 0.0 | 13.0 | 83.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| Safety margin | 310 | 1.0 | 7.0 | 89.0 | 2.0 | 1.0 | 0.0 | 0.0 | 0.0 | ||
| Safety margin | 480 | 2.0 | 23.0 | 73.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| Mean value | 1.8 | 10.8 | 83.1 | 3.4 | 0.6 | 0.0 | 0.0 | 0.3 | |||
| Standard deviation | 1.4 | 5.8 | 5.5 | 1.0 | 0.5 | 0.0 | 0.0 | 0.7 | |||
| Nevi | |||||||||||
| Nevus giganteus | 199 | 0.0 | 10.8 | 82.4 | 6.9 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| NCN | 302 | 4.0 | 19.0 | 75.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| NCN | 303 | 1.0 | 12.9 | 81.2 | 3.0 | 2.0 | 0.0 | 0.0 | 0.0 | ||
| NCN | 304 | 1.0 | 12.0 | 77.0 | 7.0 | 2.0 | 0.0 | 1.0 | 1.0 | ||
| NCN | 306 | 0.0 | 7.0 | 87.0 | 3.0 | 3.0 | 0.0 | 0.0 | 0.0 | ||
| NCN | 309 | 1.0 | 7.0 | 91.0 | 1.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| NCN | 366 | 3.0 | 13.0 | 80.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| NCN | 367 | 3.0 | 9.0 | 85.0 | 3.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| Mean value | 1.6 | 11.3 | 82.3 | 3.7 | 0.9 | 0.0 | 0.1 | 0.1 | |||
| Standard deviation | 1.4 | 3.7 | 4.9 | 2.0 | 1.2 | 0.0 | 0.3 | 0.3 | |||
| Primary melanomas | |||||||||||
| LMM | 289 | 0.0 | 11.8 | 82.4 | 4.9 | 1.0 | 0.0 | 0.0 | 0.0 | ||
| LMM | 295 | 1.0 | 2.0 | 25.0 | 13.0 | 22.0 | 19.0 | 17.0 | 1.0 | 18.0 | |
| MM | 210 | 0.0 | 8.8 | 49.0 | 32.4 | 6.9 | ND | ND | 2.9 | ||
| MM | 268 | 2.0 | 6.0 | 77.0 | 6.0 | 8.0 | 0.0 | 1.0 | 1.0 | ||
| MM | 308 | 2.0 | 4.0 | 91.0 | 2.0 | 1.0 | 0.0 | 0.0 | 0.0 | ||
| MM | 363 | 0.0 | 1.0 | 77.0 | 12.0 | 5.0 | 4.0 | 1.0 | 1.0 | ||
| NMM | 209 | 0.0 | 16.4 | 76.2 | 6.6 | 0.8 | 0.0 | 0.0 | 0.0 | ||
| NMM | 267 | 0.0 | 4.0 | 70.0 | 10.0 | 1.0 | 6.0 | 9.0 | 9.0 | ||
| NMM | 290 | 1.0 | 17.0 | 79.0 | 2.0 | 1.0 | 0.0 | 0.0 | 0.0 | ||
| NMM | 291 | 0.9 | 16.8 | 76.6 | 5.6 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| NMM | 293 | 2.0 | 5.0 | 84.0 | 7.0 | 1.0 | 1.0 | 0.0 | 0.0 | ||
| SSM | 211 | 0.0 | 7.7 | 81.7 | 7.7 | 1.9 | 0.0 | 0.0 | 1.0 | ||
| SSM | 236 | 2.0 | 13.0 | 70.0 | 8.0 | 4.0 | 0.0 | 0.0 | 3.0 | ||
| SSM | 250 | 0.0 | 5.0 | 83.0 | 7.0 | 5.0 | 0.0 | 0.0 | 0.0 | ||
| SSM | 307 | 2.0 | 10.0 | 78.0 | 6.0 | 4.0 | 0.0 | 0.0 | 0.0 | ||
| SSM | 315 | 1.0 | 5.0 | 89.0 | 4.0 | 1.0 | 0.0 | 0.0 | 0.0 | ||
| SSM | 352 | 1.0 | 11.0 | 80.0 | 6.0 | 1.0 | 1.0 | 0.0 | 0.0 | ||
| SSM | 474 | 1.0 | 10.0 | 81.0 | 8.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| Mean value | 0.9 | 8.6 | 75.0 | 8.2 | 3.6 | 1.8 | 1.6 | 2.0 | |||
| Standard deviation | 0.8 | 4.9 | 14.9 | 6.5 | 5.0 | 4.6 | 4.4 | 4.4 | |||
| Metastases | |||||||||||
| Mel.Met. | 195 | 0.0 | 8.0 | 62.0 | 27.0 | 3.0 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 205 | 0.0 | 10.9 | 76.2 | 12.9 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 206 | 0.0 | 18.8 | 75.0 | 3.8 | 2.5 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 208 | 0.0 | 13.9 | 72.3 | 8.9 | 5.0 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 218 | 2.0 | 8.0 | 80.0 | 8.0 | 2.0 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 234 | 0.0 | 4.7 | 68.0 | 26.0 | 0.7 | 0.0 | 0.0 | 0.7 | ||
| Mel.Met. | 265 | 1.0 | 0.0 | 33.0 | 14.0 | 21.0 | 27.0 | 4.0 | 4.0 | ||
| Mel.Met. | 266 | 0.0 | 1.0 | 15.0 | 7.0 | 28.0 | 44.0 | 5.0 | 5.0 | ||
| Mel.Met. | 292 | 1.0 | 2.0 | 16.0 | 18.0 | 21.0 | 19.0 | 21.0 | 2.0 | 23.0 | |
| Mel.Met. | 294 | 1.0 | 7.0 | 88.0 | 2.0 | 1.0 | 1.0 | 0.0 | 0.0 | ||
| Mel.Met. | 311 | 0.0 | 4.0 | 39.0 | 36.0 | 20.0 | 1.0 | 0.0 | 0.0 | ||
| Mel.Met. | 313 | 0.0 | 8.0 | 63.0 | 15.0 | 12.0 | 2.0 | 0.0 | 0.0 | ||
| Mel.Met. | 314 | 0.0 | 7.0 | 51.0 | 34.0 | 7.0 | 1.0 | 0.0 | 0.0 | ||
| Mel.Met. | 337 | 0.0 | 11.0 | 55.0 | 34.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 338 | 0.0 | 2.0 | 17.0 | 8.0 | 25.0 | 35.0 | 12.0 | 1.0 | 13.0 | |
| Mel.Met. | 339 | 0.0 | 7.0 | 47.0 | 14.0 | 30.0 | 1.0 | 0.0 | 1.0 | 1.0 | |
| Mel.Met. | 340 | 0.0 | 2.0 | 21.0 | 73.0 | 3.0 | 0.0 | 1.0 | 1.0 | ||
| Mel.Met. | 348 | 2.0 | 14.8 | 72.1 | 9.8 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 349 | 0.0 | 13.8 | 48.3 | 24.1 | 13.8 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 350 | 1.0 | 8.9 | 54.5 | 25.7 | 8.9 | 1.0 | 0.0 | 0.0 | ||
| Mel.Met. | 351 | 1.0 | 13.9 | 53.5 | 10.9 | 5.0 | 9.9 | 5.0 | 1.0 | 6.0 | |
| Mel.Met. | 355 | 0.0 | 1.0 | 49.0 | 48.0 | 2.0 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 364 | 1.0 | 5.0 | 66.0 | 17.0 | 3.0 | 2.0 | 6.0 | 6.0 | ||
| Mel.Met. | 365 | 1.0 | 10.0 | 46.0 | 39.0 | 1.0 | 1.0 | 2.0 | 2.0 | ||
| Mel.Met. | 369 | 0.0 | 5.0 | 84.0 | 5.0 | 3.0 | 3.0 | 0.0 | 0.0 | ||
| Mel.Met. | 370 | 1.0 | 3.0 | 27.0 | 69.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 415 | 0.0 | 5.0 | 54.0 | 39.0 | 2.0 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 416 | 0.0 | 0.0 | 16.0 | 7.0 | 11.0 | 40.0 | 22.0 | 26.0 | ||
| Mel.Met. | 417 | 0.0 | 0.9 | 34.0 | 53.8 | 9.4 | 1.9 | 0.0 | 0.0 | ||
| Mel.Met. | 418 | 1.0 | 13.0 | 82.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 420 | 0.0 | 1.0 | 9.0 | 47.0 | 40.0 | 2.0 | 0.0 | 1.0 | 1.0 | |
| Mel.Met. | 421 | 1.0 | 7.0 | 40.0 | 49.0 | 3.0 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 422 | 0.0 | 2.0 | 29.0 | 52.0 | 13.0 | 1.0 | 2.0 | 1.0 | 3.0 | |
| Mel.Met. | 423 | 1.0 | 8.0 | 74.0 | 5.0 | 2.0 | 5.0 | 3.0 | 2.0 | 5.0 | |
| Mel.Met. | 425 | 0.0 | 4.0 | 22.0 | 7.0 | 16.0 | 37.0 | 11.0 | 3.0 | 14.0 | |
| Mel.Met. | 470 | 0.0 | 4.4 | 75.0 | 15.2 | 2.2 | 2.2 | 1.1 | 1.1 | ||
| Mel.Met. | 471 | 1.0 | 8.0 | 88.0 | 3.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 473 | 0.0 | 2.9 | 57.4 | 35.3 | 1.5 | 1.5 | 1.5 | 1.5 | ||
| Mel.Met. | 475 | 0.0 | 2.0 | 11.0 | 86.0 | 1.0 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 477 | 0.0 | 5.0 | 84.0 | 8.0 | 3.0 | 0.0 | 0.0 | 0.0 | ||
| Mel.Met. | 481 | 0.0 | 8.0 | 50.0 | 37.0 | 4.0 | 0.0 | 1.0 | 1.0 | ||
| Mean value | 0.4 | 6.4 | 51.3 | 25.3 | 8.0 | 5.8 | 2.4 | 2.8 | |||
| Standard deviation | 0.6 | 4.6 | 23.6 | 21.0 | 9.7 | 12.1 | 5.1 | 5.9 | |||
NCN, nevus cell nevus. LMM, lentigo malignant melanoma. NMM, nodular malignant melanoma. SSM, superficial spreading melanoma. MM, malignant melanoma (unclassified). Mel.Met., melanoma metastasis. ND: not determined.