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. 2001 May;3(3):173–178. doi: 10.1038/sj.neo.7900158

Figure 3.

Figure 3

Autoradiographs showing specific examples of LOH for each of four different ACCs on chromosome 12. (A) Marker D12S391 for case 13. (B) Duplex PCR with marker D12S391 and B2M for case 5. (C) Marker D12S1301 for case 16. (D) Marker D12S1301 for case 18. Left lanes show assays of non-neoplastic cells (N); right lanes show assays of neoplastic (tumor) cells (T). Solid arrows denote the microsatellite allele lost in the tumor samples. In Panel B, the open arrow points to the B2M duplex PCR product, which serves as a control for the presence of DNA fragments in the sample preparation of sufficient size to amplify the larger allele in the microsatellite PCR.