Table 1.
Histopathologic Data, G-Banding Karyotype, and CGH Copy Number Changes of the 37 Breast Carcinomas.
| Case no. | Histology* | Grade† | LNM‡ | G-banding karyotype§,¶ | CGH copy number changes¶ |
| 317/92 | Com | 3,3,2 | No | 47–49,XX,add(1)(p31),der(1)add(1)(p13)add(1)(q43),+der(1)t(1;11)(q10;q10)add(1)(q42),-3,-4,-7,der(9)t(9;13)(p13;q14),del(10)(p12),-11,-13,-13,-14,-15,add(19)(p13),+4–6mar[32]/91–98,idemx2[11] | rev ish enh(1q21q22,3q24q28,6p,6q21q22,8q,16q23qter) |
| 363/92 | D | 3,2,2 | No | 44–46,XX,+7[4]/46,XX[47] | rev ish dim(1p13p31,4,9p13pter,13q14qter) |
| 386/92 | D | nd | No | 46,XX,+1,der(1;16)(q10;p10)[3]/46,XX[75] | rev ish enh(4q22qter,8p12qter,17q12q21, 20q12qter),dim(3p12p14,5q15q33,6q13q25,7q31qter,9p21pter,9q21,13q14qter,16q),amp(8q) |
| 394/92 | D | 2,2,2 | 18/18 | 48,XX,+5,+10[5]/46,XX[45] | rev ish enh(3q21q24,3q27qter,5pterq13,5q34qter,7q33qter,8p21qter,16p,17q24qter),dim(Xpterq22,11q23qter,13q14qter,16q,22q13) |
| 431/92 | Com | 3,3,3 | No | 47,XX+7[8]/46,XX[45] | rev ish enh(3p21p24,3q,4p16,8p11qter,11p14q14,14q,16p11p13,16q23qter,17q21qter,19q,20q,22q11q12),dim(1p31,4q23qter,5q11q22,6q16qter,8p22pter,9pterq33,11q23qter,20p12pter,21q21),amp(8q24,11q13) |
| 439/92 | Com | 3,1,3 | 9/11 | 66–80,XXX,+X,t(1;14)(p13;q12)x2,del(2)(q31)x2,-4,add(?6)(q14),+7,+7,+8,-9,+10,add(11)(p14),add(12)(p13),-14,-15,-17,-17,-17,-18,-19,+20,-21,+4mar[5]/46,XX[55] | rev ish enh(10q21q22) |
| 501/92 | Crib | 2,1,2 | No | 46,XX,del(4)(p12-3p15)[4]/46,XX[45] | rev ish enh(1q21q41),dim(6q16q22),amp(1q32) |
| 503/92 | D | 3,1,3 | 4/20 | 47–49,XX,+i(1)(q10),der(8)del(8)(p21)ins(8;10)(q22;q22q24),der(8)add(8)(p11)ins(8;10)(q22;q22q24),+der(8)add(8)(p11)ins(8;10)(q22;q22q24)x2,inv(9)(q12q34),-10,add(11)(q23),add(16)(q22)[cp19]/46,XX,t(1;19)(p13;q13)[4]/46,XX[10] | rev ish enh(1q21qter,8q,10q21q22),dim(8p22pter,10q25qter,16q) |
| 509/92 | D | 3,2,3 | No | 47–48,XX,+X[3]/46,XX[19] | rev ish enh(8p12qter,16p,19p,20q13),dim(6q12q21,13q21q22) |
| 512/92 | D | 3,3,3 | 19/19 | 66–67,XXX,del(3)(p13),+del(3)(p13),-4,+5,-7,-8,-8,-9,-10,-10,-13,-14,add(14)?(p11),-15,-15,-16,-17,-17,-17,-18,add(20)(q13),+add(20)(q13),-21,-21,-21,inc[2]/46,XX[55] | rev ish enh(1q21q32,7p,8q,15q,17q11q21,17q25,19,20q13,22q11q12),dim(1p21pter,1q42qter,3p21pter,4q24q28, 4q34qter,7q21q31,8p12pter,10q24qter,11q22qter,13q,18q12qter),amp(1q25q31,17q11q21) |
| 515/92 | Papil | nd | 1/8 | 47,XX,+X[2]/47,XX,+7[2]/46,XX[46] | rev ish enh(1q,4p16,4p14q24,8p12qter,12q24, 16p,17q,19,20q),dim(3p12p13,6p24pter,6q,8p22pter,10q,11q14qter,13q,14q,16q,20p12pter),amp(8q21qter,20q12qter) |
| 46/93 | Crib | 2,1,2 | No | 47,XX,+der(1;16)(q10;p10)[2]/47–48,XX,idem,+der(1;16)(q10;p10)x2,-16[cp5]/46,XX[56] | rev ish enh(1q,16p) |
| 80/93 | Com | 3,3,3 | No | 68–75,XX,-X,add(1)(p22),+add(1)(p22),-2,inv(2)(p13q37)x2,+3,del(3)(p12)x2,-4,-4,-5,-5,-5,+6,add(6)(q23)x2,add(7)(p21),+add(7)(p21),der(8)t(1;8)(p22;q24),der(8)t(3;8)(p24;p22),-10,-11,-12,dup(12)(q13q22)x2,-13,-13,-14,-15,+add(16)(p12),der(16)del(16)(p11)add(16)(q23),-17,-18,-19,-21,-22,add(22)(q13),+8mar[cp114]/46,XX[11] | rev ish enh(1p36qter,2p11p13,3p21pter,3p14qter,5q32qter,6pterq22,7,8p12qter,9p21pter,10p14p15,11p15q12,12p13,12q14q21,16p12,17p13,18pterq21,18q22qter,19p13q13.1,21q21,22q11q12),dim(X,2p21pter,2q21q32,2q35qter,4p15qter,5p14q23,6q24qter,8p23pter,13q,14q21q22),amp(6p23pter) |
| 92/93 | D+DCIS | 3,1,2 | No | 46,XX,del(6)(q21q23)[2]/46,XX[120] | rev ish enh(12q23qter) |
| 100/93 | Com | 3,3,3 | No | 46–47,XX,+7[4]/46,XX,+1,der(1;15)(q10;q10),ins(1;?)(q11;?)[2]/46,XX[64] | rev ish enh(Xq26qter,1q31q32,3p24pter,8p12qter,12q14q22,17q21q25,20q11q13),dim(Xp21pter,2p24pter,3p13p21,4q33qter,11p15,11q21qter,13q12q21,14q,16q,20p12pter,21q21q22) |
| 113/93 | D | 2,1,1 | No | 46,XX,der(3)inv(3)(p12p26)del(3)(p13p21)[4]/46,XX,t(7;9)(p14;p24)[2]/46,XX[64] | rev ish enh(1q21q42,16p),dim(12p,13q21q31) |
| 136/93 | D | 3,1,2 | No | 40–44,XX,add(1)(p34),-3,der(8)hsr(8)(p?21)hsr(8)(q24),add(11)(q21),-13,-16,+1–2mar[cp4]/46,XX,+der(1;16)(q10;p10),-10[3]/46,XX,t(5;6)(p14;q15)[2]/46,XX[85] | rev ish enh(1q22qter,6p24,9p13),dim(11q21qter,13q13qter,16q,21q) |
| 138/93 | D | 3,2,3 | No | 46,XX,t(1;20)(p13;q13)[14]/48,XX,+3mar[2]/46,XX[37] | None |
| 145/93 | D | 2,2,3 | 5/5 | 67–74,XXX,der(1)(1qter→1p36::6qter→q15::?),i(1)(q10),add(2)(q36),t(3;6)(p12;p22),-4,dic(4;16)(q31;q12),add(6)(p23),del(6)(q15),del(7)(p12),der(7)(7pter→7q11::?::3p12→3pter),i(7)(p10),-8,der(8)(1pter→1p12::?::hsr::8p22→8qter),-9,add(9)(p23),der(10)t(3;10)(p14;p13),add(11)(q14),-13,-14,-14,add(14)(p11),-15,del(16)(p11),del(16)(q12),-17,add(17)(q25),add(19)(q13),add(20)(q13),i(21)(q10),-22,+9–16mar[6]/46,XX[71] | rev ish enh(3q25qter,6p21,8q21q22,8q24,11p11p14,12p13,17q24qter,18p,22q13) |
| 167/93 | Com | 3,2,3 | 9/14 | 37–42,XX,add(1)(p11),del(2)(q23),add(3)(p12),-5,-8,-9,der(10)t(3;10)(p23;q22),der(11)t(8;11)(q12;p14),-14,-15,del(17)(p11p12),-18,-19,-21,add(22)(q12),+1–4mar[cp13]/74–80,idemx2,-add(1)(p11),+add(1)(p13)x2,-3,+der(3)t(3;8)(p12;q21),-8,+i(8)(q10)[cp15]/149–150,idemx4[2] | rev ish enh(8q21qter),dim(11p13pter,17p13) |
| 199/93 | Com | nd | No | 46,XX,del(3)(p14p22)[10]/46,X,t(X;3)(q22;p14)[5]/60–61,X,-X,-X,add(1)(p12),-2,-2,der(3)add(3)(p14)add(3)(q26),-4,-5,-5,-6,-7,-8,-8,-9,-10,-11,i(12)(p10),-13,-14,-14,-15,dic(16;?) (q23;?),-17,-17,der(20)t(5;20)(q13;p13),-21,-21, add(22)(p11),+3mar,inc[3] | rev ish enh(1q24q31,7p,13q,14q12q21),dim(3p13p22,6p22pter,8p12pter,10q25qter,11p15,11q,14q24qter,15q21qter,17p12pter,18p11.3) |
| 208/93 | Com | 3,3,3 | No | 38–41,X,-X,add(1)(p36),-2,add(3)(q2?4),del(3)(p12),add(4)(p16),der(4)t(3;4) (q2?4;q25),add(7)(q32),-8,-9,-10,der(10)t(4;10)(q21;p15),-11,der(12)inv dup(12)(q13q24)add(12)(q13),-13,-14,der(8;14)(q10;q10),-15,-15,der(17)t(3;17)(p13;p12),-18, add(19)(p13),add(21)(p11),+2mar[10]/38–41,idem,-der(12)inv dup(12)(q13q24)add(12)(q13),+der(12)inv dup(12)(q13q24)t(1;12)(q21;q13)[6]/38-41,idem,-add(1)(p36),+del(1)(q41q43),-5,+del(5)(q14q23),-6,+add(6)(q21),-add(7)(q32),+der(7)add(7)(q32)t(7;13)(p15;q12),-8,+del(12)(p11),-der(12)inv dup(12)(q13q24)add(12)(q13),-13,-14,+15,-der(17)t(3;17)(p13;p12), +der(17)t(3;17)(p13;p12)add(17)(q25),+18,+2mar[24]/76–82,idemx2,-add(1)(p36)x2,+add(1)(p12)x2[8] | rev ish enh(Xp22,1q32,2q32q33,4q12q31,6q22q24,7p14pter,8q,10p,11p14p15,12q13q22,20q12qter),dim(3p14p21,7q32qter,9p23pter,10q21qter,11q23qter,13q,14q,15q26,17p12pter,18p11.3,19q13),amp(7p21p22,8q23,10p12p14) |
| 236/93 | D+Lob | 1,1,1 | 4/14 | 46,XX,i(1)(q10)[2]/46,XX[158] | rev ish enh(16p13),dim(16q,22q13) |
| 244/93 | Muc | nd | No | 46,XX,t(3;19)(p21;q13),t(11;20)(q14;q13)[7]/46,X,der(X)t(X;3)(q22;p21),del(2)(q14),add(3)(p21),del(4)(p14p15),del(4)(q21),add(5)(p15),del(5)(q23),del(7)(q22q32),add(10)(p15),add(12)(p13),der(16)t(5;16)(q31;p13)add(16)(q23)[5]/46,XX,t(1;11)(p36;p14),-4,der(6)t(6;7)(q13;q22),add(7)(q22),der(18)t(4;18)(q13;q22),+r[3]/47,XX,t(7;19)(p15;q13)[2]/46–47,XX,t(16;17)(p11;q21)[2]/46,XX[41] | None |
| 248/93 | Com | 3,3,2 | No | 56–59,X,add(1)(p35),add(1)(p12),t(1;6)(p34;p24),add(3)(p24),dic(7;7)(q22;q22),add(10)(q22),add(11)(q22),add(16)(p13),+r,+3mar,inc[14]/46,XX,t(1;16)(p34;q23)[2]/46,XX[170] | rev ish enh(1p31p34,1p13p21,1q21q31,2p24pter,2p12p13,2q22q32,3q13qter,5p13p15,6p21qter,7p15qter,8q21qter,10p,10q11q21,11q13q22,12p,13q12q31,16p13,20q),dim(Xp11pter,1p36,3p24pter,4p11p15,4q21qter,5q11q34,8p21pter,10q23q25,11p11pter,15q22qter,18q22qter),amp(7p11p14,7q11q21,8q24) |
| 335/93 | D | 3,3,2 | 7/18 | 62–68,XX,-X,del(1)(p22),der(1)(1qter→cen→1p31::1p36→1p31::?),-2,-4,-5,add(6)(q23),+del(7)(q32),-8,-8,-9,-9,+add(12)(p13),-13,-15,-15,-16,add(16)(q23),del(16)(q22),-17,-18,-21,-22,inc[16] | rev ish enh(1p21qter,5p12p15,7pterq21,8q21qter,12,13q,17q,20) |
| 361/93 | Com | 3,2,2 | 4/24 | 59–63,XX,-X,der(1;16)(q10;p10)x2,i(1)(q10),add(13)(p11),der(19)t(7;19)(q11;q13),+der(?)t(?;5)(?;q11),inc[2] | rev ish enh(Xq27qter,1q31q32,2q23q32,4q32q34,6q21q22,6q23q24,8q11q24.1,11q13q14,12q14q22,14q12q22,20q11q13),dim(6p21.3,9p12,17p11pter,17q25,19p13) |
| 392/93 | Com | 3,1,2 | No | 79–?84,del(7)(q21),inc[2]/46,XX[67] | rev ish enh(1q24q41,3p24pter,5p13q34,6q16q22,8p11q24.1,9q13q21,9q31q34,18q12q21),dim(2q36qter,13q,17p) |
| 467/93 | D | 3,1,2 | No | 47,XX,+1,der(1;16)(q10;p10),r(?11),+20[cp19]/46,XX[21] | rev ish enh(1q,11p14p15,11q12q14),dim(11q22qter,16q) |
| 495/93 | DCIS | nd | No | 46,XX,t(8;19)(q22;q13)[2]/46,XX[12] | rev ish enh(1q23q32,1q43qter) |
| 507/93 | D | 2,3,3 | No | 46,XX,add(1)(q21)[2] | rev ish enh(1q24qter,3p24pter,3q25qter,6q15q22,7q31q32,8q22qter,9q31q33,10p13pter,11p11p15,17q23,18q12),dim(1p36,5q34qter,10q25qter,16pterq21,17p12pter) |
| 535/93 | Lob | nd | No | 62–80,XXX,+7,+10,+12,+14,+15,+mar[cp5]/46,XX[110] | rev ish enh(1q31,5q23q31,12q15q21) |
| 557/93 | D | 3,3,3 | No | 46,XX,+1,der(1;16)(q10;p10)[2]/46,XX[168] | rev ish enh(Xq25q27,1q31q32,2p24pter,4q13q21,5p,6q15q16,6q22,8q22qter,9p13pter,10p13pter,10q22,12p11p12,20q11qter),dim(8p21pter,14q24qter,15q26) |
| 566/93 | D | 2,2,1 | No | 46,XX,+1,der(1;10)(q10;p10)[2]/46,XX[81] | rev ish enh(1p13p31,1q23q32,3p22p24,3p12p14,3q24q26,4q12q33,5p13,8p12qter,12p11p12,12q21,16p11pter),dim(6p21pter,16q22qter,17p11p12),amp(8q) |
| 574/93 | D | 2,1,2 | No | 46–47,XX,t(3;6)(q21;q25)[2]/46,XX[78] | rev ish enh(1q24q32),dim(6p12p21.1,6q23qter,16q,17pterq21) |
| 2/94 | D | 3,2,3 | No | 74–80,XX,i(1)(q10)x2,+3r,inc[2]/46,XX[47] | rev ish enh(1q,5p,7p21p22,10q21q23,15q21qter,16p13,17q21qter),dim(8p,10q25qter,11q22qter,13q,16q22qter,17p12pter,18,22q),amp(1q32qter,17q22q24) |
| 7/94 | Papil | nd | No | 73–76,XXX,del(1)(q21),i(1)(?::q44→q10::q10→q44::?),del(7)(q21),add(16)(q22),del(16)(q13),inc[6]/46,XX[53] | rev ish enh(1p32qter,2p16pter,3q,5p,6p22q16,6q22q25,7p14pter,7q21,8q13qter,10p,11pterq14,12q22,13q13q32,18),dim(1p34pter,2q11q35,3p12pter,5q13q14,7q31qter,10q21q22,11q23qter,12q14q15,14q,15q11q25,17pterq12,17q24qter,20q),amp(7p21) |
*
Com, comedocarcinoma; Crib, cribriform carcinoma; D, ductal carcinoma; DCIS, ductal carcinoma in situ; D+DCIS, ductal carcinoma with extensive in situ component; Lob, lobular carcinoma; Muc, mucinous carcinoma; Papil, papillary carcinoma.
†
Histologic grade as subdivided in three components, i.e., tubule formation, mitotic activity, and nuclear pleomorphism; nd, not determined (histologic grading is done routinely only for ductal carcinoma not otherwise specified).
‡
Lymph node metastasis.
§
The G-banding karyotypes of cases 386/92, 503/92, 46/93, 136/93, 145/93, 361/93, and 467/93 were published in Tsarouha et al. [10].
¶
In bold are shown the G-banding and CGH findings that are likely to belong to the same clonal cell populations in the individual cases.