Table 1.
Correlation of Codon 201 Polymorphic Types of the DCC Gene with the Stages of Neuroblastoma.
| Stages | Number of total samples | Number (%) of codon 201Gly | Number (%) of codon 201Arg/Gly | Number (%) of codon 201Arg |
| I* | 23 | 10 (43%) | 11 (48%) | 2 (9%) |
| II* | 27 | 13 (48%) | 11 (47%) | 3 (11%) |
| III* | 16 | 9 (56%) | 6 (44%) | 0 |
| IV | 32 | 23 (72%) | 8 (25%) | 1 (3%) |
| IVs | 4 | 3 (75%) | 1 (25%) | 0 |
| Total | 102 | 58 (57%) | 38 (37%) | 6 (6%) |
| Normal control** | 21 | 8 (38%) | 10 (48%) | 3 (14%) |
The codon 201 polymorphic types of the DCC gene were significantly correlated with the stages of neuroblastoma (P=.047, by Kruskal-Wallis test). The frequency of codon 201Gly type was significantly higher in stages IV+IVs (26/36, 72%) than in stages I, II, and III (32/66, 48%) (*P=.035, by chi-square analysis) and in normal control (8/21, 38%) (**P=.024, by chi-square analysis).