Figure 5.

Alteration in proteolytic processing by FTDP-17 tau mutations. Immunoblot analysis of tau extracted from CHO cells expressing Wt and FTDP-17 mutant tau proteins showing the intact, full-length species of each tau isoform and the profile of breakdown products generated, as visualized by the T46 MAb (A) and the T1 MAb (B). The banding pattern is altered for the ΔK, RW, and VPR tau mutants relative to Wt tau, suggesting that these mutations induce a conformational change that modifies the proteolysis of these proteins.