TABLE 1.
List of brief annotations for the composite genome of HCMVa
| ORF label | Accession no. | Protein class or functional hypothesis | Features |
|---|---|---|---|
| J1L | 125058 | HCMV-specific protein | Region 205-265 is eukaryote specific; remaining regions are similar to bacterial and eukaryotic sequences; weak support for hydroxylation site at locations 294, 295, 300, 301, 307, and 308; weak support for ATP-binding site at location 238; local similarity with Q9VU12 from Drosophila melanogaster; homology with J1S_HCMVA |
| TRL1/IRL1 | 124876 | HCMV-specific transmembrane gp | Regions 32-40 and 300-310 are virus specific; remaining regions are shared among bacterial and eukaryotic sequences; N-glycosylation site at location 7; probable disulfide bridge involving the cysteines at locations 135 and 137; probable active site (of unknown nature) at location 180; support for transmembrane domain in regions 11-27, 65-85, 95-105, 140-168, and 183-195; similarity with the polycystin precursor (PKD1_HUMAN) from Homo sapiens; similarity with trans-acting transcriptional protein ICP4_HSV11 |
| TRL2/IRL2 | 124877 | HCMV-specific transmembrane gp | Support for a probable signal sequence in region 66-86; region 55-61 is virus specific (the remainder of the sequence is similar to eukaryotic sequences); N-glycosylation site at location 45; support for transmembrane domain in regions 1-33 and 100-115; similarity with a region from rat and fugu Huntingtin; similarity with the N terminus of gB precursor VGLB_HSV11; similarity with the human period circadian protein 1; similarity with a region from the middle of human and horse inhibin alpha precursor (IHA_HUMAN/IHA_HORSE) |
| TRL3/IRL3 | 124878 | HCMV-specific transmembrane protein | Support for transmembrane domain in regions 40-60 and 77-end; similarity to an NADH-ubiquinone oxidoreductase chain 6 (NU6M_ASCSU); short region shared between this sequence and ATP-dependent helicase LHR_ECOLI |
| TRL4/IRL4 | 137816 | Transmembrane gp | Support for transmembrane domain in regions 5-79 and 149-163; proline-rich in region 10-41; cytoplasmic domain in region 10-41; N-glycosylation site at locations 135 and 141; similarity with the human fas antigen ligand FASL_HUMAN |
| TRL5/IRL5 | 124879 | Inconclusive | Region 45-57 is virus specific; probable phosphorylation site at location 23; C-terminus similarity with flavoprotein subunit A (PDB: 1efv); similarity with histone 1 (H1_CHITH); similarity with the mouse period circadian protein 2; similarity to a region of the DNA polymerase from the African swine fever virus |
| TRL6/IRL6 | 124880 | HCMV-specific transmembrane gp | Region 50-65 is virus specific; N-glycosylation sites at locations 50, 56, and 62; probable transmembrane domain in region 50-94; similarity with the middle part of NADH-ubiquinone oxidoreductase chain 4 (NU4M_BALPH) |
| TRL7/IRL7 | 124881 | CMV specific | Similarity with a region of gi_202456, a zinc finger protein (Zfx) from Mus musculus; homologous to 30-kDa major early protein from strain Eisenhardt |
| TRL8/IRL8 | 124882 | HCMV specific | Serine-rich in region 85-115; glycine-rich in region 1-23 |
| TRL9/IRL9 | 124883 | Inconclusive | Probable hydroxylation site at locations 52, 62, and 65; probable triple-helical region in 53-72; probable coiled coil in region 85-118; similar to sperm protamine p1 (HSP1_ONRAN) |
| TRL10/IRL10 | 124884 | HCMV-specific transmembrane gp | Support for a signal sequence in region 1-25; N-glycosylation site at locations 48, 49, 56, and 108; support for transmembrane domain in regions 80-101; homologous to TRL10; similarity to the C terminus of NADH-ubiquinone oxidoreductase chain 6 (NU6M_BRABR) from Brachyramphus brevirostris (Kittlitz murrelet) |
| TRL11/IRL11 | 124885 | HCMV-specific transmembrane gp | Support for a signal sequence in region 5-20; support for N-glycosylation site at locations 56 and 110; support for transmembrane domain in regions 95-135 and 190-203; homologous to UL153 from the Towne strain |
| TRL12/IRL12 | 124886 | HCMV-specific transmembrane gp | O-glycosylation sites at locations 30, 33, 35, 36, 38, 43, and 44; N-glycosylation sites at locations 32, 63, 80, 83, 127, 131, 137, 198, 206, 212, 276, 286, 320, 326, and 351; support for transmembrane domain in region 370-390; weak support for an active site of unknown nature at location 323; possibly homologous to UL154 from the Towne strain |
| TRL13/IRL13 | 124887 | HCMV-specific transmembrane gp | N-glycosylation site at locations 35, 54, 89, 99, and 144; serine/threonine-rich in region 25-110; support for transmembrane domain in regions 5-18 and 125-145; good agreement with Q68408 also known as ORF UL153 from the Towne strain |
| TRL14 | 136113 | HCMV-specific transmembrane gp | N-glycosylation site at locations 24, 64, and 72; support for transmembrane domain in region 136-165; local similarity with biliary gp 1 precursor (BGP1_HUMAN); shares its N-terminal region with IR14 from the same virus; homologous with UL153 from the same virus |
| UL1 | 136774 | Transmembrane gp | N-glycosylation site at locations 6, 71, 92, 99, 110, 119, 123, 140, 157, and 161 and possibly at locations 151, 155, and 179 as well; support for transmembrane domain in regions 8-30 and 190-200; similarity to carcinoembryonic antigen |
| UL2 | 136779 | HCMV-specific transmembrane protein | Support for transmembrane domain in region 35-55; weak support for cadherin 2 domain in region 5-21; very strong similarity to a region from Homo sapiens cadherin |
| UL3 | 136780 | Transmembrane protein | Support for transmembrane domain in region 51-66; similarity to the C-terminal region of maturase O9828 from Upuna bomeensis |
| UL4 | 136785 | HCMV-specific transmembrane gp | Support for a signal sequence in region 1-25; regions 35-50 and 135-150 are virus specific; N-glycosylation site at locations 48, 53, 61, 69, 108, 112, 122, 139, and 148; weak support for phosphorylation at location 40; virtually identical to the same protein from the Towne strain |
| UL5 | 136791 | HCMV-specific transmembrane gp | Support for transmembrane domain in regions 25-35 and 115-140 |
| UL6 | 136793 | HCMV-specific transmembrane gp | Region 140-156 is virus specific; N-glycosylation site at locations 79, 102, 111, 147, 162, 174, 211, 228, and 234; support for transmembrane domain in region 235-265; similarity with protein E321_ADE1P from adenovirus; similarity with a transposase (TC1A_CAEEL) from Caenorhabditis elegans |
| UL7 | 136797 | HCMV-specific transmembrane gp | N-glycosylation sites at locations 50, 56, 60, 105, 109, 125, 132, 147, 164, 168, and 189; support for transmembrane domain in regions 26-43, 85-102, 165-180, and 191-216 |
| UL8 | 136801 | Virus-specific transmembrane gp | N-glycosylation site at locations 28 and 53; support for transmembrane domain in region 80-99; similarity with the C terminus of UL10 from the same genome |
| UL9 | 136805 | Virus-specific transmembrane gp | Region 132-140 is virus specific; N-glycosylation sites at locations 41, 93, 100, 128, and 164; support for transmembrane domain in regions 3-17, 93-125, and 191-205; homology with a large number of ORFs from the same genome |
| UL10 | 136809 | Virus-specific transmembrane gp | Region 85-95 is virus specific; N-glycosylation sites at locations 128, 172, 181, and 251; support for transmembrane domain in region 281-295; similarity with UL08 from the same genome |
| UL11 | 136814 | Virus-specific transmembrane gp | Support for a signal sequence in region 1-25; N-glycosylation site at locations 42, 84, 92, 99, and 141; support for transmembrane domain in region 230-245; polythreonine stretches in region 145-190; homology with a number of ORFs from the same genome |
| UL12 | 136820 | HCMV-specific gp | Support for a signal sequence in region 2-10; N-glycosylation site at location 38; similarity with splicing factor R/S-rich SFR3_HUMAN |
| UL13 | 136821 | HCMV-specific transmembrane gp | Support for a signal sequence in region 1-32; N-glycosylation site at locations 146, 150, 226, 356, and 437; probable active site of unknown nature at location 386; support for transmembrane domain in region 450-470 |
| UL14 | 136822 | HCMV-specific transmembrane gp | Support for a probable signal sequence in region 15-30; N-glycosylation site (at locations 160 and 255); support for transmembrane domain in regions 15-30, 280-297, and 322-337; support for disulfide bridge involving the cysteine at position 156; homologous with UL141 from the same genome |
| UL15 | 136826 | HCMV-specific transmembrane gp | Region 5-20 is virus specific; N-glycosylation site at location 285 (probably at locations 128 and 314 as well); support for transmembrane domain in regions 65-80, 130-145, 185-200, and 235-250; hydroxylation site at locations 299 and 301 |
| UL16 | 136828 | HCMV-specific transmembrane gp | Support for a signal sequence in region 6-25; N-glycosylation site at locations 35, 41, 68, 84, 95, 101, 132, and 145; support for transmembrane domain in region 190-205; substantial similarity with sequence P78996 from Saccharomyces pastorianus |
| UL17 | 136834 | HCMV-specific transmembrane protein | Support for transmembrane domain in region 66-80 |
| UL18 | 138157 | Transmembrane gp; similarity to MHCI | Support for a signal sequence in region 3-20; support for transmembrane domain in region 320-350; domain alpha-1-like (HLA class I) in region 19-114; domain alpha-2-like (HLA class I) in region 115-208; domain alpha-3-like (HLA class I) in region 209-298; N-glycosylation site at locations 56, 66, 74, 95, 123, 127, 150, 167, 177, 193, 240, 282, and 291; similarity to MHC class I antigen |
| UL19 | 136839 | Inconclusive | Probable active site at locations 31 and 97; similarity to meiotic-9 protein MEI9_DROME from D. melanogaster; similar to region from cyclolysin secretion ATP-binding protein of Bordetella pertussis |
| UL20 | 136840 | HCMV-specific transmembrane gp | Support for a signal sequence in region 2-25; region 105-120 is virus specific; N-glycosylation sites at locations 27, 54, 57, 68, 72, 78, 83, 107, 118, 146, 173, and 180; support for transmembrane domain in region 222-245 |
| UL21 | 136844 | HCMV-specific transmembrane protein | Support for a signal sequence in region 160-174; support for transmembrane domain in region 85-105; C-terminus similarity with a region from a Rhodopseudomonas palustris phosphoenolpyruvate carboxylase (CAPP_RHOPA) |
| UL21.5 | 15808850 | Inconclusive | Support for a signal sequence in region 1-20; probable coiled coil in region 86-103; homologous to the N terminus of a putative bacterial lipoprotein |
| UL22 | 136850 | Transmembrane protein | Support for transmembrane domain in regions 50-78, 85-95, and 105-119; similarity to the C terminus of cytochrome b; weak similarity to cytochrome c oxidase polypeptide III |
| UL23 | 136851 | HCMV-specific transmembrane gp | Transmembrane domain in regions 145-160 and 190-205; N-glycosylation site at location 137 |
| UL24 | 136853 | Herpesvirus specific transmembrane protein | Support for transmembrane domain in regions 60-98, 210-225, 287-305, and 317-340; shares a small region with bacterial 47.4-kDa protein O83469; similarity with ATP synthase a chain ATP6_MARPO |
| UL25 | 136862 | Herpesvirus-specific virion protein | Region 260-272 is virus specific; N-glycosylation site at locations 146, 154, and 303; polyserine in regions 1-15 and 140-160 |
| UL26 | 136868 | HCMV-specific virion gp | N-glycosylation site at location 136; support for transmembrane domain in region 55-75; probable metal binding (magnesium) at location 42 |
| UL27 | 136869 | Herpesvirus specific | Moderate support for transmembrane domain in regions 125-145, 180-195, 390-408, and 565-580; similarity with other ORFs from herpesvirus genomes |
| UL28 | 136870 | Virus-specific transmembrane protein | Moderate support for transmembrane domain in regions 35-45, 80-110, 130-145, 220-250, 260-275, and 291-310 |
| UL29 | 136871 | Herpesvirus specific | Region 1-30 is virus specific; probable disulfide bridge involving the cysteines at locations 103 and 125; polyserine in region 1-30; second half of gi_136871 is similar to the middle of gi_137158 |
| UL30 | 136872 | HCMV-specific transmembrane protein | Transmembrane domain in region 84-102; weakly similar to mitochondrial protein s14 |
| UL31 | 136874 | Herpesvirus-specific gp | Support for a signal sequence in regions 100-115 and 135-150; N-glycosylation sites at locations 275 and 296; support for hydroxylation site at location 381, 386, 390, and 393; sequence shares a small region with chmadrin Q9XS53; polyserine/threonine in region 100-125; polyglycine in region 380-400 |
| UL32 | 130702 | Virion gp | O-glycosylation site at locations 921 and 952; strong support for transmembrane domain in regions 130-150, 190-210, 305-318, 450-473, 580-600, and 895-913; polyalanine in region 345-366; polyserine in region 825-890; support for coiled coil in region 370-410 |
| UL33 | 136882 | GPCR homologue (chemokine receptor) | Support for transmembrane domain in regions 8-32, 49-73, 81-107, 117-138, 190-203, 219-245, and 270-283; similarity to galanin receptors type 3 (GPCRs) |
| UL34 | 136887 | HCMV-specific transmembrane gp | N-glycosylation site at location 30; probable phosphorylation site at location 160; support for transmembrane domain in regions 60-75, 265-278, 315-335, and 350-370; homology with O12931 from atypical cytopathic virus and stealth virus; similarity to DNA polymerase |
| UL35 | 1136891 | Herpesvirus-specific gp | N-glycosylation site at location 208 (possibly at location 515 as well); polyserine in region 495-530 |
| UL36 | 136892 | Herpesvirus specific | Polyaspartic acid/glutamic acid in region 325-335 |
| UL37 | 138325 | HCMV-specific transmembrane gp | Support for a signal sequence in region 2-22; region 95-110 is particular to eukaryotic sequences; N-glycosylation site at locations 206, 210, 219, 223, 242, 246, 275, 281, 294, 297, 306, 333, 337, 343, 379, 384, 390, and 391; support for transmembrane domain in region 435-460 |
| UL38 | 136897 | HCMV-specific transmembrane gp | Metal-binding site (iron) at location 144; N-glycosylation site at location 76; support for transmembrane domain in regions 25-45 and 130-160; probable coiled coil in region 160-195; probable disulfide bridge involving the cysteines at locations 64 and 66; C-terminal similarity to a pulative transcriptional regulator from Streptomyces coelicolor (O69988); similarity to ski oncogene; homology with ORFs from HHV-6 and HHV-7 |
| UL39 | 136898 | HCMV-specific transmembrane gp | N-glycosylation site at location 15; active site of unknown nature at location 38; support for transmembrane domain in regions 2-20 and 60-75 |
| UL40 | 136899 | HCMV-specific transmembrane gp | Support for a signal sequence in region 14-26; region 110-132 is virus specific; N-glycosylation site at locations 89, 110, and 143 (possibly at location 6 as well); support for transmembrane domain in region 175-190 |
| UL41 | 136900 | HCMV-specific transmembrane protein | Support for a probable signal sequence in region 125-141; region 1-7 is virus specific; local similarity with Q9ZV49 from Arabidopsis thaliana |
| UL42 | 136904 2454626 | HCMV-specific transmembrane gp | Region 35-60 is eukaryote specific; N-glycosylation site at location 115; polyproline in region 27-50; support for transmembrane domain in region 88-108 |
| UL43 | 1369082454627 | HCMV-specific transmembrane gp | N-glycosylation site at location 159; transmembrane domain in regions 106-115, 134-147, and 176-192 |
| UL44 | 136913 | DNA polymerase processivity factor | Region 325-400 is eukaryote specific; polyglycine in region 290-400; support for hydroxylation at locations 339 and 384; homologous to a mouse CMV phosphoprotein (Q69216) |
| UL45 | 132604 | Ribonucleoside-diphosphate reductase large-chain protein | |
| UL46 | 136918 | Herpesvirus-specific capsid protein | Support for transmembrane domain in regions 145-153 and 241-265 |
| UL47 | 136919 | Herpesvirus-specific virion protein | Region 955-981 is eukaryote specific; N-glycosylation site at locations 425 and 474 |
| UL48 | 136925 | Virion protein | Region 260-335 is eukaryote specific; support for coiled coil in regions 939-975, 985-1015, and 1292-1348; polyserine in region 330-335; homologous to Q9WJZ8, a human CMV F fragment DNA encoding DNA polymerase and gB |
| UL48.5 | xxxxx | Capsid protein | |
| UL49 | 136926 | Virus-specific transmembrane gp | Region 395-408 is virus specific; N-glycosylation site at location 237; polyalanine in region 304-323; probable transit peptide (mitochondrion) in region 1-14; probable active site of unknown nature at location 143; support for transmembrane domain in regions 138-160, 180-195, 305-320, 330-350, and 450-460; homology with a number of ORFs from other viruses |
| UL50 | 136931 | Herpesvirus-specific transmembrane protein | Support for a probable signal sequence in region 355-390; support for transmembrane domain in regions 80-100, 225-240, and 275-300; proline-rich region 200-230; homology with ORFs from other herpesviruses |
| UL51 | 136932 | Virus-specific transmembrane protein | Support for transmembrane domain in regions 45-55 and 133-145; similarity to a region of a DNA polymerase from herpes simplex virus (DPOL_HSV21); homology with ORFs from other viruses |
| UL52 | 136938 | Herpesvirus-specific transmembrane gp | Region 555-574 is virus specific; N-glycosylation sites at locations 142, 145, 295, and 453; hydroxylation site at location 412; probable coiled coil in region 375-413; support for transmembrane domain in regions 582-598 and 609-625; homology with ORFs from other herpesviruses |
| UL53 | 136944 | Virus specific | Regions 94-105, 144-155, and 204-215 are virus specific; polyserine in region 310-340; coiled coil in region 260-300 |
| UL54 | 1169409 | DNA polymerase | Region 645-680 is eukaryote specific; polyserine in region 640-680; N-glycosylation site at location 661 (possibly at location 345 as well); support for a disulfide bridge involving the cysteines at locations 304 and 313 |
| UL55 | 138192 | Virion gp; gB | Support for a signal sequence in region 1-25; N-glycosylation site at locations 37, 68, 73, 85, 208, 281, 286, 302, 341, 383, 405, 409, 417, 447, 452, 464, 465, 554, and 585; region 25-705 is extracellular; region 773-end is cytoplasmic; support for transmembrane domain in region 705-770 |
| UL56 | 136950 | Terminase DNA-packaging protein | Support for a signal sequence in region 1-5; region 440-490 is eukaryote specific; N-glycosylation site at locations 127, 446, 449, and 458; probable transmembrane domain in regions 240-265, 545-573, 595-626, 640-665, 700-720, and 780-790; polyserine in region 435-460; homology with many viral sequences |
| UL57 | 118745 | Single-stranded DNA-binding protein | Region 535-600 is eukaryote specific; zinc finger (c2hc type) in region 467-481; polyglycine in region 540-587; probable transmembrane domain in regions 40-55, 125-152, 345-355,425-445, 455-480, 680-705, and 1170-1185; N-glycosylation site at location 999; probable triple helical domain in region 534-588; ATP binding in region 799-807; hydroxylation site at locations 541, 547, and 1195 |
| UL58 | 136953 | Transmembrane protein | Region 62-70 is virus specific; probable transmembrane domain in region 17-33; similarity to the N-terminal region of nodulation protein from Rhizobium fredii |
| UL59 | 136954 | HCMV-specific transmembrane protein | Probable phosphorylation site at locations 101 and 103; support for transmembrane domain in regions 50-65 and 83-95 |
| UL60 | 136955 | HCMV specific | Transmembrane domain in regions 30-60 and 140-160; this sequence shares similarity with an extended region of “spike” glycoprotein e2 from Simliki Forest virus (POLS_RRVT/POLS_SFV) |
| UL61 | 136956 | HCMV-specific transmembrane protein | Regions 305-315 and 380-405 are eukaryote specific; possible cell attachment site in region 229-232; support for transmembrane domain in regions 140-160 and 205-220; hydroxylation site at locations 24, 26, 225, 227, 238, 264, 311, 383, and 391; probable triple-helical region in region 375-400; similarity to the N-terminal region of a (probable) nuclear antigen from pseudorabies virus (strain Kaplan) (VNUA_PRVKA) |
| UL62 | 138957 | HCMV specific | Regions 1-15 and 160-175 are eukaryote specific; hydroxylation site at location 159 and 169; polyserine in region 1-20 |
| UL63 | 136958 | HCMV-specific transmembrane protein | Region 68-75 is virus specific; support for transmembrane domain in regions 7-25 and 45-65 |
| UL64 | 136959 | HCMV specific | Transmembrane domain in region 35-54; similarity to a region of a valyl-tRNA synthetase from Synechocystis sp. (SYV_SYNY3) |
| UL65 | 136960 | Virion protein | Similarity to the N terminus of the 67-kDa tegument protein TEGU_HCMV |
| UL66 | 136961 | HCMV specific | Short C terminus similarity with sperm protamine p1 from Alouatta seniculus |
| UL67 | 136962 | HCMV specific gp | Region 50-64 is eukaryote specific; N-glycosylation site at locations 20 and 97; probable phosphorylation site at location 62 |
| UL68 | 136963 | HCMV-specific transmembrane gp | Region 60-80 is eukaryote specific; probable N-glycosylation site at location 92; support for transmembrane domain in region 7-24; similarity to the C terminus of a homeobox protein from Xenopus laevis (HMD4_XENLA) |
| UL69 | 136964 | Transcriptional regulator | Regions 170-210 and 690-720 are eukaryote specific; polyproline in region 700-718; support for transmembrane domain in regions 480-491 and 525-550; ie63 homolog |
| UL70 | 136965 | DNA helicase or primase | N-glycosylation site at location 730 |
| UL71 | 136966 | Herpesvirus specific | Region 310-340 is eukaryote specific; moderate support for transmembrane domain in region 215-240; probable coiled coil in region 80-105; 15 of the 20 amino acids of a DNA-binding (helix-tum-helix) motif are in region 279-293; similarity to the C-terminal region of DNA-directed RNA polymerase (RPOB_SALTY, RPOB_ECOLI, and RPOB_BUCAP) |
| UL72 | 118954 | Deoxyuridine 5′-triphosphate nucleotide hydrolase | |
| UL73 | 136967 | Herpesvirus-specific transmembrane protein | Support for a signal sequence in region 2-20; region 75-end is particular to viral sequences; support for transmembrane domain in region 100-122 |
| UL74 | 136968 | HCMV-specific transmembrane gp; gO | N-glycosylation site at locations 75, 83, 87, 103, 130, 157, 162, 171, 219, 242, 288, 292, 350, 385, 392, 399, 433, and 454; support for transmembrane domain in regions 10-28 and 190-212; probable coiled coil in region 240-272 |
| UL75 | 138313 | Virus specific transmembrane gp; GH | Support for a signal sequence in region 1-22; N-glycosylation site at locations 56, 63, 68, 193, 642, and 701; support for transmembrane domain in region 720-735 |
| UL76 | 136969 | Virus specific | Transmembrane domain in regions 40-60 and 73-95; probable ATP binding in region 2-9 |
| UL77 | 136970 | Virus specific virion protein | N-glycosylation site at locations 210, 246, and 263; support for transmembrane domain in regions 2-15, 115-125, 155-165, 430-450, 465-480, 518-530, 550-560, and 630-642 |
| UL78 | 136971 | GPCR homologue (purinoreceptor-like) | N-glycosylation site at location 105; transmembrane domain in regions 43-60, 74-95, 110-131, 155-180, 204-222, 236-255, and 280-300; there is support for similarity with NADH-ubiquinone oxidoreductase chains 4 and 6 |
| UL79 | 136972 | Virus specific | Transmembrane domain in regions 130-170 and 205-217; sequence appears to contain glimpses of a kinase domain; very good conservation of this protein across the herpesviruses |
| UL80 UL80a UL80.5 | 139232 | Maturational proteinase; assembly scaffold protein | Cleavage by the protease in regions 256-257 and 643-644; active site (charge relay system) at locations 63, 132, and 157; support for transmembrane domain in regions 8-18, 45-60, 66-80, 340-365, and 670-687 |
| UL81 | 136973 | HCMV specific | |
| UL82 | 130716 | Virion protein | Site involved in the formation of salt bridges at location 238; probable stromal domain in region 359-373; possible transmembrane domain in regions 120-145, 200-220, 323-345, 460-475, and 480-500 |
| UL83 | 130714 | Virion protein | Phosphorylation site at location 472; N-glycosylation site at location 93; active site of unknown nature at location 184; probable binding site (calcium) in region 398-409; similarity between its C terminus and the C terminus of gi_2352031_gb_AAC60369.1_, a Tuple1/HirA protein from Fugu rubripes |
| UL84 | 136974 | HCMV-specific transmembrane protein | Polyglutamic acid/aspartic acid in region 150-183; polyarginine in region 9-19; support for transmembrane domain in regions 43-50 and 225-240 |
| UL85 | 139190 | Virus specific minor capsid protein | Region 1-12 is virus specific; N-glycosylation site at locations 67 and 297 |
| UL86 | 137570 | Major capsid protein | Probable calcium-binding site in region 520-530; site involved in the control of polyamine-mediated channel gating at location 637; probable N-glycosylation site at locations 341, 526, and 637; site acylated by penicillin at location 1256 |
| UL87 | 136976 | Virus-specific transmembrane gp | Regions 340-360 and 910-935 are virus specific; N-glycosylation site at locations 37, 591, 661, and 801; polyglycine in region 340-365; polyserine in region 900-end; support for transmembrane domain in regions 85-95, 570-590, and 813-825; probable triple-helical region in 341-362 |
| UL88 | 136978 | Herpesvirus-specific virion protein | |
| UL89 | 139645 | Terminase DNA-packaging protein | Probable N-glycosylation site at location 329 |
| UL90 | 136980 | hcmv specific | |
| UL91 | 136981 | Herpesvirus specific | Support for a probable signal sequence in region 1-19 |
| UL92 | 136984 | Herpesvirus-specific transmembrane protein | Region 129-141 is virus specific; support for transmembrane domain in regions 35-50, 90-105, and 144-162; very well conserved across many viruses |
| UL93 | 136986 | Virus-specific transmembrane protein | Support for transmembrane domain in regions 125-135, 420-440, 475-490, and 529-550; GPI anchor at location 235; homologous to a sequence from rhesus CMV (strain 68-1) (Q9YUG2) |
| UL94 | 136987 | Virus-specific transmembrane protein | Region 73-90 is virus specific; support for transmembrane domain in regions 95-115, 165-199, 205-228, 279-305, and 329-345; probable disulfide bridges involving the cysteines at locations 243, 250, 252, and 256; similarity with a number of viral sequences |
| UL95 | 136989 | Herpesvirus-specific transmembrane gp | Region 50-100 is eukaryote specific; polyglycine in region 375-395; polyserine in region 45-100; support for transmembrane domain in region 375-395; N-glycosylation site at location 190 |
| UL96 | 136991 | Herpesvirus specific | Probable active site at location 43 |
| UL97 | 136993 | Phosphotransferase (ganciclovir kinase) | Regions 270-285 and 410-422 are virus specific; ATP binding in region 337-345; polyalanine in region 40-65; active site (of unknown nature) at locations 454, 456, and 461; weak support for the presence of a calcium-binding region in 696-707 |
| UL98 | 119692 | DNase | Probable transmembrane domain in regions 170-195, 240-270, 305-318, 390-415, and 525-535 |
| UL99 | 130711 | Virion protein | |
| UL100 | 136994 | GPCR homologue; gM | Region 1-10 is virus specific; support for transmembrane domain in regions 15-35, 80-100, 150-172, 200-220, 240-260, 270-285, and 299-319; D/E-rich in region 359-end; N-glycosylation site at locations 56 and 113 |
| UL102 | 136996, 603226 | DNA helicase/primase | Polyserine in region 795-840 |
| UL103 | 136997 | Herpesvirus-specific transmembrane gp | Support for transmembrane domain in regions 57-70, 95-110, and 220-230; N-glycosylation site at location 20; similarity of a C-terminus region to an N-terminus region from cytochrome b |
| UL104 | 136998 | Transmembrane gp | N-glycosylation sites at locations 354, 457, and 570; support for transmembrane domain in regions 61-75, 173-185, 215-240, 395-420, and 570-590; hydroxylation site at locations 684, 687, and 693 (possibly at 391 and 394 as well); similarity with sequences from many viruses |
| UL105 | 122808 | DNA helicase/primase | ATP binding in region 120-127 |
| UL106 | 136999 | HCMV specific | Local similarity with a bacterial dehydrogenase (Q9ZHH7) |
| UL107 | 137000 | HCMV-specific gp | N-glycosylation site at location 144 |
| UL108 | 137001 | HCMV-specific gp | N-glycosylation site at location 69; moderate support for transmembrane domain in regions 50-77 and 106-123; similarity with two regions from NU5M_CHOCR; similarity to the N terminus of DNA polymerase from woodchuck hepatitis virus (DPOL_WHV1/DPOL_WHVW6) |
| Y13K | 139947 | Transmembrane protein | Support for transmembrane domain in region 91-116; similarity to the C-terminal region of cytochrome b |
| Y9K | 140150 | Transmembrane gp | Probable N-glycosylation site at locations 3 and 27; support for transmembrane domain in regions 5-24 and 45-60; weak similarity to the C terminus of yeast protein phosphatase regulatory subunit |
| UL109 | 137002 | Inconclusive | Probable active site at locations 69 and 72; probable phosphorylation site at locations 96 and 98; a small region of the C terminus of this sequence is shared with FACA_HUMAN (Fanconi anemia group A); similar to an N-terminal region of a putative dehydrogenase from S. coelicolor |
| UL110 | 137003 | HCMV specific | |
| UL111 | 137004 | HCMV-specific transmembrane protein | Weak support for transmembrane domain in regions 7-21 and 74-85; region 1-121 shows good similarity to the N-terminal region of glutamate gated chloride channel beta subunit precursor from Haemonchus contortus (P91730) |
| UL111.5 | 137012 | IL-10-like protein | Support for a signal sequence in region 2-15 |
| UL112 | 137005 | Early phosphoprotein p34 | Poly-glycine in region 200-220; homologous to the N terminus of EP84_HCMVA, O10418, and O10417 from the same genome |
| UL112-113 | 137006 | Early phosphoprotein p84 | Polyglycine in region 86-111; shares region 70-150 with O10417 from the same strain, O10418 from the same strain, and Q69215 (Pp43) from the Towne strain; probable N-glycosylation site at locations 140, 141, 410, 423, and 444 |
| UL114 | 137036 | Uracil glycosylase | Active site at location 91 |
| UL115 | 2506510 | Virus-specific gp; gL | Support for a signal sequence in region 1-35; N-glycosylation sites at locations 74 and 114; similarity with citrate synthase |
| UL116 | 137008 | Virus-specific transmembrane protein | N-glycosylation sites at locations 58, 73, 87, 107, 132, 133, 139, 181, 200, 247, 253, 282, 285, and 298; support for transmembrane domain in regions 40-70, 290-300, and 307-320 |
| UL117 | 137009 | Herpesvirus-specific transmembrane gp | Support for a signal sequence in region 165-200; N-glycosylation site at locations 247, 309, and 396; support for transmembrane domain in regions 165-200, 230-250, 310-321, and 390-410; extensive similarity shared with a group of herpesvirus sequences |
| UL118 | 137010 | HCMV-specific transmembrane gp | Support for a signal sequence in region 1-15; N-glycosylation sites at locations 12, 43, 62, 81, 89, 105, 108, and 124; support for transmembrane domain in region 160-180; similarity with vesicular inhibitory amino acid transporter; substantial similarity to NADH-ubiquinone oxidoreductase chain 2; similar to gi_1052835_gb_AAB00492.1 and gi_1616985_gb_AAB16887.1_; homologous to Q9PY29, a late transcript from HHV-5 (see MEDLINE; 92015512) |
| UL119 | 137011 | HCMV-specific gp | Support for a signal sequence in region 1-15; polyserine in region 23-74; N-glycosylation site at locations 34, 48, 95, and 104 |
| UL120 | 137013 | CMV-specific transmembrane gp | N-glycosylation sites at locations 46, 49, 55, 84, 95, 113, 122, 137, 144, and 187; support for transmembrane domain in regions 4-30 and 174-190; similar to UL120 from Macaca mulatta CMV and BOLF3 from simian CMV; C-terminal similarity to the VPU protein of human immunodeficiency virus |
| UL121 | 137014 | CMV-specific transmembrane gp | Support for a signal sequence in region 5-25; N-glycosylation site at location 104; support for transmembrane domain in regions 10-24, 94-110, and 140-160; similarity with cytochrome c oxidase polypeptide ii precursor (COX2_BACFI); similarity with (i) (M93360) ORF UL121 M. mulatta CMV and (ii) (U38308) BOLF4 simian CMV |
| UL122 | 138482 | Transcriptional regulatory protein, IE2 | Zinc finger in region 258-274; polyglycine/serine in region 90-152 |
| UL123 | 138476 | Virus-specific, transcriptional regulatory protein, IE1 | Polyglutamic acid/aspartic acid in region 420-472; support for transmembrane domain in regions 116-135, 180-195, and 300-310 |
| UL124 | 137015 | Transmembrane gp | Support for a signal sequence in region 2-25; support for transmembrane domain in region 82-100; N-glycosylation site at locations 33, 46, and 64; local similarity with an adenylate cyclase type V from rat (CYA5_RAT); local similarity with trans-acting transcriptional activator protein icp4 from Marek's disease herpesvirus |
| UL125 | 137016 | HCMV-specific transmembrane protein | Support for transmembrane domain in region 5-16; similarity with a region of SN22_HUMAN, a possible global transcription activator; similarity with a region of a cyclin-dependent kinase inhibitor 1C from H. sapiens (CDNC_HUMAN) |
| UL126 | 137017 | HCMV-specific gp | N-glycosylation site at locations 16 and 33; local similarity with a region from Q9VN01 from D. melanogaster; similarity with protamine 2 from rat (gi_56968); similarity with a piece of sperm histone P2 from H. sapiens (HSP2_HUMAN) |
| UL127 | 137018 | HCMV-specific transmembrane gp | N-glycosylation site at location 97; probable transmembrane domain in regions 84-102 and 115-127; similarity to a bacterial helix-tum-helix in RP54_KLEPN; similarity to the C-terminal region of viral DNA polymerases |
| UL128 | 137019 | HCMV-specific transmembrane gp | N-glycosylation site at location 55; support for transmembrane domain in regions 25-40 and 85-100; moderate support for nucleotide phosphate binding (GTP) in region 13-16 |
| UL129 | 137020 | HCMV-specific transmembrane protein | Support for transmembrane domain in regions 35-45 and 95-112 |
| UL130 | 137021 | CMV-specific gp | Support for a signal sequence in region 1-25; N-glycosylation site at locations 85, 118, and 201; methylation site at location 145; moderate local similarity with protein kinase C-like 1 |
| UL131 | 137022 | HCMV-specific transmembrane gp | N-glycosylation site at location 70; support for transmembrane domain in region 10-28; homology with Q69208 (transforming domain III from HCMV) and Q68827 (Towne strain); similarity to the middle of a RNA polymerase alpha subunit from Haemophilus influenzae |
| UL132 | 137023 | HCMV-specific transmembrane gp | Support for a signal sequence in region 2-20; region 190-205 is virus specific; N-glycosylation site at locations 31, 61, and 245; polyserine/threonine in region 30-60; support for transmembrane domain in region 80-107; weak support for O-glycosylation site at locations 60, 63, 64, and 68 |
| UL132/Toledo | 1167934 | HCMV-specific transmembrane gp | Support for a signal sequence in region 1-20; region 190-205 is specific to viral sequences; polyserine/threonine in region 30-60; support for transmembrane domain in region 80-107; N-glycosylation site at locations 31, 72, and 245; homologous to ULD2_HCMVA and to Q68830 from strain Towne |
| UL133/Toledo | 1167918 | HCMV-specific transmembrane protein | Region 1-12 is specific to viral sequences; support for a disulfide bridge involving the cysteines at locations 87 and 97; support for transmembrane domain in regions 15-30, 45-65, and 230-245 |
| UL134/Toledo | 1167919 | HCMV-specific transmembrane protein | Moderate support for transmembrane domain in region 145-175 |
| UL135/Toledo | 1167920 | HCMV-specific transmembrane protein | Polyserine in region 145-165; support for transmembrane domain in region 25-45 |
| UL136/Toledo | 1167921 | HCMV-specific transmembrane protein | Support for transmembrane domain in region 60-90 |
| UL137/Toledo | 1167922 | HCMV-specific | |
| UL138/Toledo | 1167923 | HCMV-specific transmembrane protein | Support for transmembrane domain in region 5-30; polyserine in region 95-130 |
| UL139/Toledo | 1167924 | HCMV-specific transmembrane gp | Support for a signal sequence in region 1-15; transmembrane domain in region 55-72; N-glycosylation site at locations 24 and 90; polyserine in region 10-40 |
| UL140/Toledo | 1167925 | HCMV-specific transmembrane protein | Support for transmembrane domain in regions 20-45 and 55-70 |
| UL141/Toledo | 1167926 | Transmembrane gp | Hydroxylation site at location 412; possible disulfide bridge involving the cysteines at locations 154 and 230; N-glycosylation site at locations 204, 219, and 234; support for transmembrane domain in regions 210-220 and 365-387; local similarities shared with YDEC_SCHPO, a putative DNA repair protein from Saccharomyces pombe; similarity with UL14 from the same genome |
| UL142/Toledo | 1167927 | HCMV-specific transmembrane gp | Region 160-175 is virus specific; support for transmembrane behavior domain in regions 55-70 and 275-290; N-glycosylation site at locations 32, 166, 171, and 176 |
| UL143/Toledo | 1167928 | HCMV-specific transmembrane gp | Support for transmembrane domain in region 70-83; probable nucleotide phosphate binding (FAD/ATP part) in region 32-46; N-glycosylation site at location 54 |
| UL144/Toledo | 1167929 | Transmembrane protein related to tumor necrosis factor receptor | Support for a probable signal sequence in region 1-15; region 65-110 is virus specific; support for transmembrane domain in region 135-159; similarity to a eukaryotic tumor necrosis factor receptor (Q9UM65) |
| UL145/Toledo | 1167930 | HCMV specific | Moderate similarity with ACPM_SCHPO, a putative acyl carrier protein, mitochondrial precursor (NADH-ubiquinone oxidoreductase) |
| UL146/Toledo | 1167931 | HCMV-specific transmembrane protein | Region 51-56 is virus specific; support for transmembrane domain in region 3-15; homologous with Towne strain UL152_HCMVA |
| UL147/Toledo | 1167932 | HCMV-specific transmembrane protein | Support for a signal sequence in region 15-44; support for transmembrane domain in region 55-65 |
| UL147/Towne | 1167940 | HCMV-specific chemokine | Support for transmembrane domain in regions 25-40 and 55-75; active site of unknown nature at location 4; probable N-glycosylation site at location 54 |
| UL148/Toledo | 1167933 | HCMV specific | Support for a signal sequence in region 1-19; region 60-71 is virus specific |
| UL149/Toledo | 1167936 | HCMV specific | Support for a signal sequence in region 35-52; region 95-120 is eukaryote specific; active site of unknown nature at location 3; local similarity with Q13424 alpha-1 syntrophin from H. sapiens |
| UL150/Toledo | 1167937 | HCMV-specific transmembrane protein | Region 1-20 is eukaryote specific; hydroxylation site at location 215; support for transmembrane domain in regions 275-295, 330-350, and 595-611 |
| UL151/Toledo | 1167938 | HCMV-specific transmembrane protein | Support for transmembrane domain in regions 50-60, 90-100, and 140-160 |
| UL152/Towne | 1167941 | HCMV-specific chemokine | Signal peptide in region 1-15; homologous with UL146/Toledo |
| UL153/Towne | 1167942 | HCMV-specific transmembrane gp | Regions 120-130 and 265-277 are virus specific; support for transmembrane domain in region 235-260; polyserine/threonine in region 10-75; N-glycosylation site at locations 20, 168, and 233; homologous with TR14_HCMVA |
| UL154/Towne | 1167943 | CMV-specific transmembrane gp | Support for transmembrane domain in region 355-373; polyserine in region 90-110; moderate support for N-glycosylation site at locations 106, 119, 150, 162, 189, and 224 |
| IRL14 | 124888 | HCMV-specific gp | Region 1-35 is virus specific; region 70-95 is eukaryote specific; remaining regions are bacterium-eukaryote specific; N-glycosylation site at location 24; calcium-binding site at location 150; shares its N terminus with TRL14 from the same genome |
| IRL13 to IRL1 | See TRL13 to TRL1 | See TRL13 to TRL1 | |
| J1I | 125057 | HCMV-specific gp | N-glycosylation sites at locations 50 and 233; support for disulfide bridges involving the cysteines at locations 131, 134, 137, and 142; similarity with J1L_HCMVA and J1S_HCMVA from the same genome |
| IRS1 | 124910 | HCMV-specific gp | Bacterium-eukaryote specific; N-glycosylation site at locations 76, 118, and 223; hydroxylation site at locations 12, 64, 68, and 71; acetylation site at location 820; phosphorylation site at location 721; similarity with NUFM_CAEEL, a putative NADH-ubiquinone oxidoreductase 17.3-kDa subunit; similarity with the immediate-early protein ie180 IE18_PRVIF (pseudorabies virus); there is also a similarity with the middle and the C terminus of a β-lactamase precursor from E. coli (AMPC_ECOLI); quasi-identical to gi_136375 of the same genome |
| US1 | 137122 | HCMV-specific transmembrane gp | Region 140-170 is eukaryote specific; N-glycosylation sites at locations 48 and 208; polyserine in region 145-170; support for transmembrane domain in regions 12-30 and 60-75; similarity to a region of OL56_STRAT (S. antibioticus), an oleandomycin polyketide synthase (modules 5 and 6) |
| US2 | 137123 | HCMV-specific transmembrane gp | Region 148-164 is virus specific; N-glycosylation sites at locations 68, 172, and 188; support for transmembrane domain in region 165-190; similarity with putative NADH-ubiquinone oxidoreductase chain 2 (NU2M_CHICK) |
| US3 | 137128 | HCMV-specific transmembrane gp | Support for a signal sequence in region 1-15; region 45-65 is virus specific; N-glycosylation site at locations 60 and 68; support for transmembrane domain in region 156-186; good similarity with US02_HCMVA |
| US4 | 137129 | HCMV-specific transmembrane protein | Region 45-60 is eukaryote specific; support for transmembrane domain in region 104-117; active site of unknown nature at location 17; similarity with the RNA polymerase RPOD_SULSO |
| US5 | 137130 | HCMV specific | |
| US6 | 137133 | HCMV-specific transmembrane gp | Support for a signal sequence in region 1-19; N-glycosylation site at location 52; support for transmembrane domain in region 155-170 |
| US7 | 137134 | Transmembrane gp | Support for a signal sequence in region 1-15; N-glycosylation site at locations 69 and 205; support for transmembrane domain in region 170-190; US07_HCMVA, US11_HCMVA, US08_HCMVA, and US09_HCMVA share various regions in various orders; similarity to the C-terminal region of a cytochrome c oxidase polypeptide i from Leishmania tarentolae |
| US8 | 137135 | HCMV-specific transmembrane gp | Support for a signal sequence in region 1-21; regions 50-55 and 149-157 are virus specific; N-glycosylation site at location 61; support for transmembrane domain in region 180-200; hydroxylation site at location 90; similarity with US7 and US9 from the same genome; also, some similarity with regions from enolases |
| US9 | 137136 | HCMV-specific transmembrane gp | Support for a signal sequence in region 6-26; region 20-60 is eukaryote specific; support for transmembrane domain in region 195-213; N-glycosylation site at locations 97 and 158; probable disulfide bridge involving the cysteines at locations 9 and 16; similarity with Huntingtin |
| US10 | 137137 | HCMV-specific transmembrane gp | Support for a signal sequence in region 1-25; transmembrane domain in region 150-170; N-glycosylation site at locations 111 and 143 |
| US11 | 137143 | HCMV-specific transmembrane gp | Support for a signal sequence in region 2-15; N-glycosylation site at location 73; support for transmembrane domain in region 185-203; similarity with truncated testis-specific box 1-less prolactin receptor from Gallus gallus (gi_2295649); similarity with the C terminus of the β-galactosidase precursor from Arthrobacter sp. (BGAL_ARTSP); similarity with US09 and US07 from the same genome |
| US12 | 137144 | GPCR homologue (delta opioid receptor) | Support for transmembrane domain in regions 65-75, 115-135, 145-167, 175-195, 200-220, 250-258, and 265-275 |
| US13 | 137145 | HCMV-specific GPCR homologue | Strong support for transmembrane domain in regions 30-49, 70-88, 95-112, 120-145, 155-165, 180-195, and 210-235; extended similarity with cytochrome b from Hansenula wingei (CYB_HANWI); weaker similarity with mouse NADH-ubiquinone oxidoreductase chain 4 (NU4M_MOUSE) |
| US14 | 137146 | GPCR homologue (calcitonin receptor) | Support for transmembrane domain in regions 63-90, 105-118, 130-145, 155-165, 185-198, 210-225, and 255-269; N-glycosylation site at locations 291 and 299; similarity with an ATP synthase (ATP6_MYCTU) |
| US15 | 137147 | HCMV-specific GPCR homologue | Support for transmembrane domain in regions 95-115, 188-210, 275-292, 355-378, 390-405, 415-430, and 450-475 |
| US16 | 137148 | HCMV-specific GPCR homologue | N-glycosylation site at location 178; active site of unknown nature at location 117; support for transmembrane domain in regions 50-65, 90-103, 130-145, 155-175, 190-202, 215-230, and 250-265; similarity with ATP synthase from Synechocystis sp. |
| US17 | 137149 | HCMV-specific GPCR homologue | N-glycosylation site at location 287; support for transmembrane domain in regions 55-70, 85-95, 110-128, 140-158, 166-182, 195-210, and 235-250; similarity with US18 from the same genome; similarity with NADH-ubiquinone oxidoreductase chain 2 (NU2M_SYMSY and NU2M_RHIUN) |
| US18 | 137150 | HCMV-specific GPCR homologue | Support for transmembrane domain in regions 50-68, 80-97, 110-125, 140-155, 170-185, 195-210, and 230-250; N-glycosylation site at location 242; helix-tum-helix-like motif in region 190-230; similarity with an ATP synthase (ATP6_ARTSF); similarity with NADH-ubiquinone oxidoreductase chain 5 (NU5M_DROYA) |
| US19 | 137151 | HCMV-specific GPCR homologue | Support for transmembrane domain in regions 25-45, 65-85, 95-115, 125-145, 155-170, 185-200, and 220-238; reasonable quality alignment with NADH-ubiquinone oxidoreductase chain 1 (NU1M_ANOGA and NU1M_DROME) |
| US20 | 549171 | HCMV-specific GPCR homologue | N-glycosylation site at locations 149, 176, and 330; support for transmembrane domain in regions 119-140, 150-168, 180-193, 205-225, 235-250, 265-286, and 296-315; support for a disulfide bridge involving the cysteines at locations 287 and 292; local similarity with a region of AAF60456 from C. elegans; similarity with NADH-ubiquinone oxidoreductase chain 5 from Anopheles quadrimaculatus (NU5M_ANOQU); the ORF is embedded in the middle of a sequence from rhesus CMV |
| US21 | 137153 | GPCR homologue | Support for transmembrane domain in regions 15-35, 55-65, 80-96, 105-125, 140-152, 162-176, and 190-210; similarity with a genome polyprotein (POL1_BAYMJ) that contains an RNA-directed RNA polymerase from Barley yellow mosaic virus (Japanese strain II-1) (BaYMV); similarity with an ATP synthase a chain from A. quadrimaculatus (mosquito) (ATP6_ANOQU); similarity with cytochrome b from Erinaceus europaeus (Western European hedgehog) CYB_ERIEU; homologous to gi_3348079 from rhesus CMV; similarity with the newly sequenced CGI-119 from H. sapiens (gi_4929707_gb_AAD34114.1_AF151) |
| US22 | 137154 | Transmembrane gp | N-glycosylation site at locations 410, 411, and 507; support for transmembrane domain in regions 55-70 and 290-310; active site (charge relay system) at location 531; shares a small region with cg10951 from D. melanogaster |
| US23 | 137155 | HCMV-specific transmembrane protein | Region 10-25 is virus specific; support for transmembrane domain in regions 65-73, 208-218, and 250-265; probable binding site for GlcNAc-1-p at location 121; homologous with Q9QJ47 from HHV-6B |
| US24 | 137156 | HCMV-specific transmembrane gp | N-glycosylation site at location 200; support for transmembrane domain in regions 260-275 and 285-301; lipid GPI anchor site at location 2; similarity with AF078102 rhesus CMV and with (U10326) ORF HJ7 SwissProt accession number P09722 (mouse CMV 1) |
| US25 | 137157 | HCMV-specific transmembrane protein | Support for probable signal sequence in region 1-14; region 150-end is eukaryote specific; support for transmembrane domain in region 36-59; amidation site at location 121; local similarity with Q9V4J6 from D. melanogaster |
| US26 | 137158 | Herpesvirus specific, transmembrane gp | N-glycosylation site at locations 44, 478, 482, 517, and 521; polyglutamic acid/aspartic acid in region 490-525; support for transmembrane domain in regions 270-294 and 315-340 |
| US27 | 137159 | GPCR homologue (chemokine receptor) | Support for transmembrane domain in regions 35-58, 68-90, 105-126, 149-167, 194-213, 234-257, and 275-298; probable pyridoxal phosphate-binding site at location 61; N-glycosylation site at locations 7, 15, 18, and 22; similarity with galanin receptors type 2 and 3 (GPCRs) |
| US28 | 137160 | GPCR homologue (chemokine receptor) | Region 290-322 is eukaryote specific; strong support for transmembrane domain in regions 28-55, 64-94, 105-125, 145-160, 180-205, 225-240, and 275-290; N-glycosylation site at location 30; similarity with galanin receptors type 2 and 3 (GPCRs) |
| US29 | 137161 | HCMV-specific transmembrane gp | Region 40-75 is eukaryote specific; N-glycosylation site at locations 54, 98, and 182; support for transmembrane domain in regions 140, 173, 219-232, 260-280, and 363-390; probable NADP binding in region 225-231 |
| US30 | 137162 | HCMV-specific transmembrane gp | Support for a signal sequence in region 51-65; support for transmembrane domain in region 225-255; N-glycosylation site at locations 75, 98, and 140 |
| US31 | 137163 | HCMV-specific gp | Support for signal sequence in region 1-23; region 55-66 is virus specific; N-glycosylation site at location 182 (possibly at location 165 as well); poly-serine in regions 120-140 and 160-183; similarity with an RNA2 polyprotein from the tobacco black ring virus (POL2_TBRVS); similarity with the core of a DNA polymerase from the hepatitis B virus (DPOL_HPBVW); similarity with a region from an ATP-dependent helicase recg from Synechocystis sp. (RECG_SYNY3) |
| US32 | 137164 | Inconclusive | Region 1215-140 is eukaryote specific; hydroxylation site at locations 129, 131, and 135; similarity to an ATP-dependent DNA helicase from Thiobacillus ferrooxidans |
| US33 | 137165 | HCMV-specific metalloprotein | Probable metal-binding site (zinc) at location 78; similarity with 8-amino-7-oxononanoate synthase from M. tuberculosis (BIOF_MYCTU) |
| US34 | 137166 | HCMV-specific gp | Region 148-end is eukaryote specific; N-glycosylation site at locations 55, 79, 133, and 152 |
| US35 | 137167 | HCMV-specific transmembrane gp | N-glycosylation site at location 51; support for transmembrane domain in region 38-50 |
| US36 | 137168 | HCMV-specific transmembrane gp | N-glycosylation site at locations 14 and 96; phosphorylation site at location 90; support for transmembrane domain in region 50-65 |
| TRS1 | 136375 | hcmv-specific gp | N-glycosylation site at locations 76, 118, and 223; polyalanine in region 360-460; hydroxylation site at location 12, 68, 71, and 756; the N-terminal half of this ORF is identical to gi_124910_sp_P09715_IRS1_HCMVA |
| J1S | 125059 | HCMV specific | Regions 90-150 and 175-195 are eukaryote specific; the remaining regions are bacterium-eukaryote specific; polyproline in regions 90-110 and 175-190; probable hydroxylation site at locations 177, 178, 184, 185, 189, and 190; probable ATP-binding site at location 121; homologous with gi_125058_sp_P17143_J1L_HCMVA 137 from the same genome |
a
The following terms are used in this table: gp, glycoprotein; eukaryote specific, used in the features column to characterize a region and indicating that the majority of the seqlets matching somewhere in the region had instances primarily within eukaryotic sequences; bacterium specific, used in the features column to characterize a region and indicating that the majority of the seqlets matching somewhere in the region had instances primarily within bacterial sequences; virus specific, used in the features column to characterize a region and indicating that the majority of the seqlets somewhere in the region matched primarily within viral sequences and used in the functional hypothesis column to indicate that any identifiable sequence similarities are with viral sequences only; herpesvirus specific, used in the functional hypothesis column to indicate that any identifiable sequence similarities are with herpesvirus sequences only; CMV specific, used in the functional hypothesis column to indicate that any identifiable sequence similarities are with cytomegalovirus sequences only; HCMV specific, used in the functional hypothesis column to indicate that any identifiable sequence similarities are with HCMV sequences only. Regions expressed in the form N-M, with N and M integers, indicate all amino acids of the respective ORF between positions N and M inclusive. Finally, we make a distinction between “homologous” and “similar” sequences: we use the first adjective to refer to groups of sequences when there is reason to believe that they are evolutionarily related and the second adjective to refer to groups of sequences that are related to one another as deduced with the help of a similarity search tool and a scoring matrix. CMV, cytomegalovirus; MHC, major histocompatibility complex; GPI, glycophosphatidylinositol; gB, glycoprotein B, etc.