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Mutation of the CDK2/cyclin E phosphorylation site in coilin at S184 to alanine results in nucleolar and CB localization. GFP-coilin(S184A) was transfected into HeLa cells. Immunofluorescence with antibodies to fibrillarin showed complete colocalization with GFP-coilin(S184A). Approximately 30% of transfected cells show this phenotype; the rest of the cells appear normal.
