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. 2001 Nov;3(6):535–546. doi: 10.1038/sj.neo.7900203

Figure 3.

Figure 3

Structure and function of XIAP. Functional domains of the XIAP protein. Baculoviral inhibitor of apoptosis repeat (BIR) domains is essential for the caspase-inhibitory function of XIAP. XIAP inhibits both the initiator caspase-9 and the effector caspase-3 and -7. XAF1, XIAP-associated factor 1. The function of the BIR1 domain of XIAP is still unclear.