FIG. 4.

Efficiency of IE1 epitope recognition in A2Kb and HHD II transgenic mice after recAAV vector immunization. HHD II mice (A to C) and A2Kb (D to F) mice were injected with 1.5 × 10⁸ IU of recAAV-IE1. Splenocytes, collected 30 days postimmunization, were stimulated in vitro with a mixture of IE1 peptides. (A and D) Recognition of endogenously processed IE1; (B and E) cytotoxicity against T2 cells sensitized with the same peptide-IE1 mix; (C and F) recognition of individual peptides is shown for HHD II mice and A2Kb mice, respectively.