TABLE 2.
Down-regulated genes in both MCF+FIR and MCF+SOD cells
| GenBank no. | Gene name | Gene functiona | Foldb change in:
|
|
|---|---|---|---|---|
| MCF+FIR/control | MCF+SOD/MCF-7c | |||
| M32315 | TNF receptor 2 precursor | Apoptosis | 4.5 | 4.6 |
| U69611 | TNF-α converting enzyme | Apoptosis | 4.4 | 4.0 |
| Y09392 | WSL-LR (Apo-3) | Apoptosis | 3.9 | 3.0 |
| L13689 | DNA-binding protein BMI-1 | Signal transduction | 4.2 | 2.4 |
| X60188 | Extracellular signal-regulated kinase 1 | Signal transduction | 2.4 | 2.9 |
| M10901 | Glucocorticoid receptor alpha | Transcription factor | 3.6 | 3.5 |
| Q00421 | GA-binding protein beta-2 chain | Transcription factor | 2.0 | 3.5 |
| D12763 | ST2 protein precursor | Cytokine | 3.6 | 2.1 |
| M16961 | Alpha-2-HS-glycoprotein precursor | Insulin tyrosine kinase inhibitor | 4.9 | 4.3 |
| L10240 | Basin precursor | Collagenase | 4.3 | 5.2 |
| M24283 | Intercellular adhesion molecule 1 precursor | Cell adhesion | 3.5 | 3.2 |
| M14091 | Thyroxine-binding globulin (TBG) precursor | TBG function | 3.1 | 3.7 |
| M59911 | Integrin alpha-3 | Adhesion molecules | 2.2 | 3.5 |
| M96995 | Growth factor receptor-bound protein 2 | T4-binding globulin | 2.1 | 3.2 |
| X53795 | Inducible membrane protein R2; CD82 | Tumor suppressor antigen | 4.4 | 9.8 |
| L12693 | Cellular nucleic acid-binding protein | Unknown | 3.7 | 9.1 |
a
Gene function was updated by MedLine database searches.
b
Results represent the quantitation of one hybridization of two sets of fluorescence-labeled RNA probes, not including values with changes of less than twofold.
c
MCF+FIR profiles were obtained by normalizing gene expression levels of MCF+FIR radioresistant clone 8 to the level of the revertant MCF+FIR clone 10 (shown in Fig. 3A); MCF+SOD profiles were obtained by normalizing expression levels of the MCF+SOD cell line to the level in wild-type MCF-7 cells.