TABLE 1.
Assessment of fertilizing ability of CD46-disrupted micea
| Male genotype | Avg litter size (no. of births) of female of indicated genotype
|
Fertilization (%) of oviductal eggs (total no. of eggs/no. of females) | |||
|---|---|---|---|---|---|
| Expt 1
|
Expt 2
|
||||
| CD46−/− | CD46+/+ | C57BL/6 | DBA/2N | B6D2F1 | |
| CD46−/− | 8.2 ± 2.1 (20) | 9.0 ± 2.4 (21) | 8.9 ± 1.9 (39) | 7.5 ± 2.2 (67)∗ | 92.1 ± 7.2 (302/10)∗ |
| CD46+/+b | 7.4 ± 1.3 (10) | 7.9 ± 1.8 (16) | 9.0 ± 2.1 (40) | 6.5 ± 2.6 (57) | 83.3 ± 8.1 (315/10) |
a
The results are expressed as means ± standard deviations. The number of females used is indicated in parentheses. At least five different males were used in each experiment. All comparisons were made using the males from the same litter. In experiment 3, the eggs were recovered from the oviduct and were assessed for fertilization. ∗, P < 0.02 compared to results for CD46+/+ males.
b
CD46+/+ and CD46−/− mice used were littermates.