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Ectopic de novo methylation affects polytene chromosome structure. (A) Overexpression of Dnmt3a resulted in loss of polytene chromosome organization in salivary glands. (B) Higher magnification of a single nucleus. Bars, 10 μm. (C) Overexpression of the catalytically inactive Dnmt3a protein had no effect. (D) Higher magnification of a single nucleus. Nuclei with hypermethylated DNA frequently appeared smaller and showed indications of DNA underreplication.
