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. 2000 Dec;11(12):4309–4321. doi: 10.1091/mbc.11.12.4309

Figure 1.

Figure 1

PHO regulation system. A simplified schematic of the PHO regulation mechanism showing the five main regulator proteins is illustrated (Johnston and Carlson, 1992; Oshima, 1997). Ovals and boxes represent proteins and genes, respectively. Thick lines mean that the signals are transduced to the downstream component, while dotted lines indicate the absent of an interaction with the downstream component. Open ovals and boxes indicate active states, gray oval and boxes indicate inactive state. The PHO5-constitutive mutants used in this study are listed to the right of the corresponding mutated protein with the nature of the mutation indicated by “gain” or “loss” of function.