Table 1.
Homologs of the Human Oncogenes and Tumor Suppressors in Rodents, Flies and Nematodes.
| Gene symbol | Hum_acc | Mouse_acc | Prot_id | Fly_acc | Prot_id | Nem_acc | Prot_id |
| HRAS | J00277 | Z50013 | 99.5 | M16429 | 76.4 | ZK792.6 | 74.6 |
| KRAS2 | M54968 | M16429 | 78.8 | ZK792.6 | 77.1 | ||
| NRAS | X02751 | M12124 | 98.4 | M16429 | 75.7 | ZK792.6 | 74.1 |
| EGFR/ERBB-1 | X00588 | AF109077 | 35.2 | ZK1067.1 | 27.7 | ||
| ERBB2/HER2/NEU | M11730 | X03362# | 87.3 | AF109080 | 32.5 | *ZK1067.1 | 27.1 |
| ERBB3/HER3 | M34309 | U29339# | 90.4 | AF109079 | 31.6 | ZK1067.1 | 25.6 |
| ERBB4/HER4 | L07868 | AF041838 | 96.6 | AF109077 | 34.3 | ZK1067.1 | 26.7 |
| RAF1 | X03484 | M15427 | 98.3 | X07181 | 44.2 | Y73B6A.A | |
| E2F1 | M96577 | L21973 | 86.2 | X78421 | Y48C3A.T | 20.4 | |
| GTBP/MSH6 | U28946 | U42190 | 86.1 | *U17893 | Y47G6A_242.C | ||
| CRK | D10656 | S72408 | 98.7 | AF112976 | 42.9 | Y41D4A_3457.B | |
| MLH1 | U07418 | U80054# | 86.9 | AF068257 | 46.0 | T28A8.7 | 33.5 |
| JUN | J04111 | J04115 | 97.3 | X54144 | 31.1 | T24H10.2 | |
| JUNB | X51345 | U20735 | 93.6 | X54144 | 30.5 | T24H10.2 | |
| JUND | X56681 | J05205 | 95.1 | X54144 | 32.1 | T24H10.2 | |
| DCC | X76132 | X85788 | 96.5 | U71001 | 32.2 | T19B4.7 | 26.4 |
| TAL1 | M61108 | M59764 | 93.6 | AL024485 | 27.1 | T15H9.3 | 19.0 |
| ERG | M17254 | S66169* | 98.0 | *X68259 | 26.6 | T08H4.3 | 33.1 |
| FLI1/ERGB2 | X67001 | X59421 | 85.6 | *X68259 | 24.3 | T08H4.3 | 33.2 |
| ETS1 | J04101 | X53953 | 97.3 | X69166 | *T08H4.3 | 23.3 | |
| ETS2 | J04102 | J04103 | 92.1 | *X68259 | 26.8 | *T08H4.3 | 24.7 |
| CDKN1B/KIP1 | U10906 | U09968 | 88.3 | T05A6.2 | |||
| CDKN1C/KIP2 | U22398 | U22399 | 61.4 | T05A6.2 | 20.2 | ||
| ABL1 | X16416 | J02995 | 82.2 | M19692 | M79.1 | 34.5 | |
| CBL | X57110 | X57111 | 93.1 | AJ223175 | M02A10.3 | ||
| APC | M74088 | M88127 | 90.6 | U77947 | 24.9 | K04G2.8B | |
| MSH2 | U03911 | X81143 | 92.4 | U17893 | 41.5 | H26D21.2 | 28.9 |
| MSH3 | U61981 | M80360 | 81.5 | *U17893 | 23.1 | *H26D21.2 | |
| FGR(SRC2) | M19722 | X16440 | 86.3 | D42125 | 53.7 | F49B2.5 | 46.2 |
| FYN | M14333 | U35365# | 99.3 | D42125 | 55.0 | F49B2.5 | 48.5 |
| HCK | M16591 | J03023 | 90.1 | D42125 | 52.3 | F49B2.5 | 45.2 |
| LCK | M36881 | X03533 | 96.4 | D42125 | 49.5 | F49B2.5 | 43.4 |
| LYN | M16038 | M57696 | 95.9 | D42125 | 51.0 | F49B2.5 | 43.9 |
| SRC | AF077754 | M17031 | 98.9 | D42125 | 54.0 | F49B2.5 | 47.9 |
| YE1 | M15990 | X67677 | 96.3 | D42125 | 53.0 | F49B2.5 | 48.3 |
| R0S1 | M34353 | X81650 | 80.5 | M34545 | 23.3 | *F49B2.5 | |
| MAX | X66867 | M63903 | 98.1 | U77369 | 41.6 | F46G10.6 | |
| MYC | J00120 | X00195 | 91.6 | U77370 | *F46G10.6 | ||
| PIM1 | M24779 | M13945 | 93.9 | *AL031765 | F45H7.4 | 36.0 | |
| CDK4 | U37022 | L01640 | 94.7 | X99510 | 43.7 | F18H3.5B | 36.3 |
| MET | J02958 | Y00671 | 89.6 | *U18351 | F11E6.8 | ||
| BCR | Y00661 | *AL031884 | C38D4.5 | ||||
| ELK1 | M25269 | X87257 | 85.7 | *M88475 | C37F5.1 | 27.3 | |
| ELK3 | Z36715 | Z32815 | 91.4 | *M20408 | *C37F5.1 | 28.6 | |
| BRCA1 | U14680 | U31625 | 57.3 | *AJ001514 | C36A4.8 | ||
| VAV1 | X16316 | X64361 | 93.1 | *L12446 | C35B8.2 | 27.6 | |
| AKT1 | M63167 | X65687 | 98.1 | Z26242 | 56.8 | C12D8.10B | 52.7 |
| AKT2 | M95936 | U22445 | 98.1 | Z26242 | 57.2 | C12D8.10B | 51.2 |
| BCL3 | M31732 | AF067774 | 82.3 | L03367 | 19.6 | C04F12.3 | |
| NF1 | M89914 | L10370* | 98.5 | L26500 | 54.0 | *ZK899.8D | |
| PTCH/PTC | U43148 | U46155 | 96.1 | X17558 | 31.6 | *ZK6751 | 25.2 |
| CCND1 | M64349 | S78355 | 93.2 | U41808 | *Y38F1A5 | ||
| CCND2 | M90813 | M83749 | 92.4 | U41808 | *Y38F1A5 | ||
| CCND3 | M92287 | U43844 | 94.9 | U41808 | *Y38F1A.5 | ||
| WNT1 | X03072 | M11943 | 98.9 | M17230 | *W01B6.1 | 38.3 | |
| WNT2 | X07876 | X64735 | 38.9 | *W01B6.1 | 40.4 | ||
| THRA | M24898 | M25804# | 94.1 | *X51548 | *T01B10.4 | 23.6 | |
| MADH4/DPC4 | U44378 | U79748 | 99.2 | AF019753 | *R12B2.1 | 31.4 | |
| CDH1/E-CAD | Z13009 | X06115 | 81.7 | *AB002397 | *R10F2.1 | ||
| FER | J03358 | U76762 | 92.8 | X52844 | 36.4 | *M79.1 | |
| FES/FPS | X06292 | X12616 | 90.0 | *X52844 | 36.7 | *M79.1 | |
| EPHA1 | M18391 | U18084* | 80.3 | *AF146648 | 33.9 | *M03A1.1 | 25.5 |
| MCC | M62397 | *K12F2.1 | |||||
| PMS1 | U13695 | *AF068271 | 23.7 | *H12C20.2A | 23.0 | ||
| PMS2 | U13696 | U28724 | 74.7 | AF068271 | 40.9 | *H12C20.2A | 33.6 |
| CSF1R | X03663 | X06368 | 74.6 | *X74031 | 26.1 | *F58A3.2 | 23.1 |
| KIT | X06182 | Y00864 | 92.7 | *X74031 | 25.6 | *F58A3.2 | 23.5 |
| RET | M57464 | X67812 | 85.8 | D16401 | *F58A3.2 | 23.5 | |
| WT1 | X51630 | M55512 | 96.7 | *U42402 | *F56F11.3 | 21.7 | |
| MOS | J00119 | J00372 | 74.7 | *K01042 | 21.1 | *F33E2.2 | |
| MYB | U22376 | X05939 | 31.4 | *F32H2.1B | |||
| TGFBR2 | D50683 | D32072 | 91.9 | *L22176 | 29.9 | *F29C4.1 | 23.3 |
| CDKN2B/INK4B | AF004819 | *AF132196 | *D2021.8 | ||||
| RB1 | M15400 | M26391 | 91.9 | *AL031583 | 22.9 | *C32F10.2 | 20.3 |
| MCF2/DBL | X12556 | *D86546 | *C14A11.3 | ||||
| TIAM1 | U16296 | U05245 | 94.8 | D86546 | *C11D9.1 | ||
| FGF3/INT2 | X14445 | Y00848 | 82.4 | *U82273 | *C05D11.4 | ||
| FGF4/HSTF1 | J02986 | X14849 | 81.2 | *U82273 | *C05D11.4 | ||
| FGF6/HST2 | X63454 | X51552 | 93.4 | *U82273 | *C05D11.4 | ||
| NF2 | L11353 | L28176 | 98.2 | U49724 | 46.0 | *C01G8.5A | 41.6 |
| NTRK3/TRKC | U05012 | L14445# | 97.1 | AF037164 | 26.7 | *C01G6.8 | 22.9 |
| TRK | M23102 | M85214# | 86.5 | *AF037164 | 28.1 | *C01G6.8 | 22.7 |
| NFKB2 | X61498 | AF053614 | 23.8 | *B0350.2B | |||
| CDKN2A/INK4A | L27211 | AF059567 | 85.3 | *AF132196 | |||
| REL | X75042 | X60271 | 75.6 | M23702 | 29.5 | ||
| MAS1 | M13150 | X67735 | 88.9 | *M77168 | |||
| MYCN | Y00664 | X03919 | 85.4 | *U77369 | |||
| MYCL1 | M19720 | X13944 | 90.4 | U77370 | |||
| BCL2 | M14745 | L31532 | 89.0 | ||||
| BRCA2 | U43746 | U65594 | 59.1 | ||||
| CDKN1A/WAF1 | U03106 | U09507 | 78.2 | ||||
| FOS | V01512 | V00727 | 93.7 | ||||
| FOSB | L49169 | AF093624 | 95.6 | ||||
| FOSL1/FRA1 | X16707 | AF017128 | 90.0 | ||||
| FOSL2/FRA2 | X16706 | X83971 | 95.1 | ||||
| PDGFB | M12783 | M84453 | 99.2 | ||||
| SKI | X15218 | U14173* | 92.8 | ||||
| THRB | X0470 | S62756 | 95.8 | ||||
| TP53 | X54156 | X00741 | 76.8 | ||||
| VHL | AF010238 | U12570 | 84.5 | ||||
NOTE. Included for each human gene in this set are: its official gene symbol (column 1), GenBank accession no. (column 2), rodent (mouse or rat) GenBank accession no (column 3), protein percentage identity between the human and rodent proteins (column 4) D. melanogaster GenBank accession no. (column 5), protein percentage identity between the human and fly proteins (column 6), C. elegans nematodepep identification no. (column 7), protein percentage identity between the human and nematode proteins (column 8). Percentage identity is only reported if the protein length for the other organism is within 20% of the human query length. An asterisk preceding the GenBank no. in columns 5 and 7 denotes that the match did not meet the “reciprocal BLAST” criterion (see text). The framed boxes correspond to the 19 groups that share the same matches in D. melanogaster or C. elegans (see text).