Table 3.

Dephosphorylation of p53 by Various Phosphatases.

Phosphatases	General	Inducers	p53 modification	Effect on p53	References
PP2A	major kinase phosphatase in eukaryotic cells	?	ser378	reduces DNA sequence-specific binding of p53; reduces apoptosis	[153,176,177]
PP5	participates in cell cycle checkpoint control	UV light reduces PP5 mRNA	?	reduces p53's transactivation activity	[178]
hCDC14A&B	birds to C-terminal domain of p53; dephosphorylate Cdc2 and Cdk2 substrates; involved in exit of mitosis in yeast	?	ser315	expected to favor tetramerization by removing inhibitory ser315 phosphorylation; increased stability? nuclear localization?	[151,179,283]
?	ATM-dependent activation of unknown phosphatase	IR	ser376	creating a binding site for 14-3-3 protein resulting in increased sequence-specific DNA binding	[105]