Table 4.

Acetylation and Ribosylation of p53.

Modifier	General	Inducer	p53 modification	Effect on p53	References
P300	acetyl transferase; acetylation of p53 favored if N-terminus of p53 is phosphorylated; functions in the apoptotic response to IR	UV, IR	acetylation of lys382 both in vitro/in vivo	increases sequence-specific binding of p53; increases stability of p53	[85,86,180–182]
PCAF	acetyl transferase; acetylation of p53 favored if N-terminus of p53 is phosphorylated	UV, IR	acetylation of lys320 both in vitro/in vivo	increases sequence-specific binding of p53	[86,181]
PARP	abundant chromatin-bound enzyme activated by DNA strand breaks; ribosylates itself, histones and other proteins; plays role in strand break and base excision repair; interacts with p53	IR, not UV	ribosylates sites within central core and C-terminal domain	increases p53 stability; increases transactivation of target genes	[183–194]