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. 2000 Nov;2(6):496–504. doi: 10.1038/sj.neo.7900116

Figure 4.

Figure 4

Purified human liver cathepsin B degraded DQ-BSA (A) and DQ-collagen IV (B) at both acidic and neutral pH. CA074, a highly selective inhibitor of cathepsin B, totally blocked degradation of the two DQ-substrates at both pHs. S=substrate: DQ-BSA (A) or DQ-collagen IV (B); S+E=substrate+enzyme (cathepsin B); S+E+I=substrate+enzyme+inhibitor (10 µM CAO74). Results represent three independent experiments performed in triplicate and are expressed as a percentage of 100% relative fluorescence (RF) for S+E at pH 5.2; mean±SD. In columns without standard deviations, they were too small to depict.