Figure 1.

(A) Time course for TPZ-induced DNA damage in RIF-1 tumors in mice given a single intraperitoneal dose of 0.08 mmol/kg TPZ as measured with the alkaline comet assay. The data show the mean and standard errors for groups of three mice per time point. (B) Dose response for TPZ-induced DNA damage in RIF-1 tumors as measured with the alkaline comet assay. Fine-needle aspirates were taken from tumors 45 minutes after intraperitoneal injection of different TPZ doses. Means and standard errors for three to five tumors treated per point are shown.