Table 2.
Magnetic resonance and histology characterization of experimental brain tumors in TSP1 derived peptide-treated and control animals.
| 9L-GFP-34-1 | C6 | |||
| TSP1 derived | Control peptide | TSP1 derived | Control peptide | |
| Tumor size (mm3) | 50.7±44.2 | 215.7±67.8 | 41.3±34.2 | 184.4±74.4 |
| rVVF of tumor* | 1.89±0.21 | 2.26±0.30 | 2.10±0.20 | 2.00±0.20 |
| Vascularity† | ||||
| Hypovascular | 5.1±2.1 | 5.2±4.0 | 4.9±4.0 | 5.3±3.3 |
| Isovascular | 61.7±18.1 | 53.3±7.1 | 58.9±14.2 | 65.8±9.9 |
| Hypervascular | 33.2±21.2 | 41.5±10.8 | 36.2±9.5 | 28.9±7.0 |
| Vascular area fraction, %‡ | 5.06±1.76 | 5.58±1.81 | ND | ND |
| Vessel count, per mm2 | 39 | 37 | ND | ND |
*
Scaled to VVF of the contralateral normal brain.
†
Percentage compared to the contralateral normal brain±2SD.
‡
Determined using fluorescent microscopy and anti-CD-31 as described in Materials and Methods.
ND=not determined.