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Immunohistochemical analysis of a rat 9L gliosarcoma grown s.c. in a nude mouse 2 days after direct injection of 1x106 t.u. of HSV/AAV hybrid amplicon vectors that express tk. The immunohistochemical staining for thymidine kinase (brown cells) reveals a transduction rate of approximately 1% to 10% around the injection site (▽).
