Table 4.
Compound | Dose (mg/kg) | Treatment Schedule | TI% | TF/T |
Control | Diluant* | i.v. days 1, 2, 3 | 0 | 0/10 |
3-IAABE | 15 | i.v. daily x4 x2 | 43 | 0/10 |
3-IAABE | 25 | i.v. 1, 2, 3 | 85 | 2/10 |
Paclitaxel | 30 | i.v. q3 x3 | 90 | 0/10 |
Vinblastine | 3 | i.v. q6d x3 | 80 | 0/10 |
N,N-dimethylacetamide, propylene glycol and Tween 80 (1:2:1 v/v/v).
NOTE. (1) 2.5x106 tumor cells were injected s.c. on day 0, treatment started at day 1. (2) TI%= Tumor growth inhibition 1 week after last treatment. (3) TF/T=Tumor-free mice at day 90 after tumor implant.