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. Author manuscript; available in PMC: 2006 Jul 15.
Published in final edited form as: Nat Immunol. 2002 Nov;3(11):999–1005. doi: 10.1038/ni1102-999

Figure 2. Natural selection of tumor variants in the generation of “tumor escape” phenotypes.

Figure 2

(a) Genomic instability gives rise to genetic diversity in tumors. Natural selection of tumor variants occurs by differential propagation of tumor subclones in their microenvironment. (b) The same concept also applies to tumor growth after effective immunotherapy.