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. 2002 Jan 15;109(2):269–276. doi: 10.1172/JCI13997

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Copyright © 2002, American Society for Clinical Investigation

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Female mice heterozygous for deletion of the Man/GalNAc-4-SO₄ receptor have smaller numbers of pups per litter. M/G4S-R^+/+ and M/G4S-R^+/– female mice were bred with both M/G4S-R^+/+ and M/G4S-R^+/– male mice. The number of pups born was determined the morning of delivery. There was no apparent difference in appearance or survival rate following delivery. Bars indicate the median value for each group. Mean values of 4.7 (n = 63) for female M/G4S-R^+/– × male M/G4S-R^+/–, 5.2 (n = 25) for female M/G4S-R^+/– × male M/G4S-R^+/+, 9.0 (n = 11) for female M/G4S-R^+/+ × male M/G4S-R^+/–, and 9.8 (n = 20) for female M/G4S-R^+/+ × male M/G4S-R^+/+ pups per litter were obtained. ANOVA analysis using Tukey’s multiple comparison test indicated that differences between the means of female M/G4S-R^+/– × male M/G4S-R^+/– and female M/G4S-R^+/– × male M/G4S-R^+/+, or between female M/G4S-R^+/+ × male M/G4S-R^+/– and female M/G4S-R^+/+ × male M/G4S-R^+/+, were not significant (P > 0.05). Differences between the means for either female M/G4S-R^+/– × male M/G4S-R^+/– or female M/G4S-R^+/– × male M/G4S-R^+/+, and either female M/G4S-R^+/+ × male M/G4S-R^+/– or female M/G4S-R^+/+ × male M/G4S-R^+/+, were highly significant (P < 0.001).