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. 2002 Jan 15;109(2):269–276. doi: 10.1172/JCI13997

Figure 3.

Figure 3

Female mice heterozygous for deletion of the Man/GalNAc-4-SO4 receptor ovulate normally but have a reduced rate of implantation. (a) Eggs were collected from genotyped mice the morning following estrus and counted. An unpaired t test indicated that the mean values of 8.2 for M/G4S-R+/– female mice and 8.7 for M/G4S-R+/+ female mice were not significant (P = 0.40). (b) Genotyped mice were given subcutaneous injections of P4 (2 mg per mouse) on day 3, and P4 (2 mg per mouse) + E2 (10 ng per mouse) on day 4. Mice were injected with Chicago sky blue 6B in saline on day 5 shortly before sacrifice, and the number of implantation sites demarcated as localized blue bands (8) was counted. Bars indicate the median. ANOVA analysis using Tukey’s multiple comparison test indicated that the difference between the mean value of 5.1 for M/G4S-R+/– female mice and 8.6 for M/G4S-R+/+ female mice is significant (P < 0.05) whereas the difference between the means of 7.1 for M/G4S-R+/– female mice treated with P4 and E2 and 8.6 for M/G4S-R+/+ female mice was not significant (P > 0.05).