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LH is cleared from the circulation more slowly by M/G4S-R+/– mice than by M/G4S-R+/+ mice. [125I]bLH was injected into M/G4S-R+/– and M/G4S-R+/+ mice, and 50 μl of blood was withdrawn from a cannula in the jugular vein at the times indicated. The amount of radioactivity in each sample was determined on a γ-counter. The curves shown were generated with Prism 2.0 (GraphPad Software Inc., San Diego, California, USA) using the equation for exponential decay with a single component.
